Cipro XR and Paclitaxel protein-bound
Determining the interaction of Cipro XR and Paclitaxel protein-bound and the possibility of their joint administration.
In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.
Consumer:Consumer information for this minor interaction is not currently available. Some minor drug interactions may not be clinically relevant in all patients. Minor drug interactions do not usually cause harm or require a change in therapy. However, your healthcare provider can determine if adjustments to your medications are needed.
Professional:Limited data suggest that chemotherapy with antineoplastic agents may reduce the plasma concentrations of oral quinolone antibiotics. The proposed mechanism is decreased quinolone absorption secondary to alteration of intestinal mucosa by cancer chemotherapy. In six patients with newly diagnosed hematologic malignancy, treatment with various antineoplastic agents (cyclophosphamide, cytarabine, daunorubicin, doxorubicin, mitoxantrone, prednisolone, vincristine) decreased the mean peak serum concentration (Cmax) and area under the concentration-time curve (AUC 0 to 4 hours) of ciprofloxacin by approximately 46% each. Data are not available for other quinolone antibiotics.
- Johnson EJ, MacGowan AP, Potter MN, et al "Reduced absorption of oral ciprofloxacin after chemotherapy for haematological malignancy." J Antimicrob Chemother 25 (1990): 837-42
Generic Name: ciprofloxacin
Brand name: Cipro, Cipro XR, Proquin XR, Cipro IV
Synonyms: n.a.
Generic Name: paclitaxel protein-bound
Brand name: Abraxane
Synonyms: PACLitaxel (Protein Bound)
In the course of checking the drug compatibility and interactions, data from the following reference sources was used: Drugs.com, Rxlist.com, Webmd.com, Medscape.com.
- Cipro XR-Paclitaxel protein-bound Intravenous
- Cipro XR-Pacnex
- Cipro XR-Pacnex LP
- Cipro XR-Pacnex MX
- Cipro XR-Pain Enz Topical
- Cipro XR-Pain Relief PM Extra Strength
- Paclitaxel protein-bound-Ciprofloxacin
- Paclitaxel protein-bound-Ciprofloxacin (Systemic)
- Paclitaxel protein-bound-Ciprofloxacin Extended-Release Tablets
- Paclitaxel protein-bound-Ciprofloxacin in 5% Dextrose
- Paclitaxel protein-bound-Ciprofloxacin injection
- Paclitaxel protein-bound-Ciprofloxacin Injection Concentrate