Cipro XR and Valium
Determining the interaction of Cipro XR and Valium and the possibility of their joint administration.
In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.
Consumer:Consumer information for this minor interaction is not currently available. Some minor drug interactions may not be clinically relevant in all patients. Minor drug interactions do not usually cause harm or require a change in therapy. However, your healthcare provider can determine if adjustments to your medications are needed.
Professional:A pharmacokinetic interaction between ciprofloxacin and diazepam has been reported in one study. Patients pretreated with ciprofloxacin experienced a prolongation of the elimination half-life of diazepam and a decrease in the plasma clearance of diazepam. These alterations in the kinetic parameters of diazepam were not associated with alterations in the pharmacologic effects of diazepam. The clinical implications of these findings are unknown.
- Kamali F, Thomas SH, Edwards C "The influence of steady-state ciprofloxacin on the pharmacokinetics and pharmacodynamics of a single dose of diazepam in healthy volunteers." Eur J Clin Pharmacol 44 (1993): 365-7
Generic Name: ciprofloxacin
Brand name: Cipro, Cipro XR, Proquin XR, Cipro IV
Synonyms: n.a.
Generic Name: diazepam
Brand name: Valium, Diastat, Diastat AcuDial, Diastat Pediatric, Diazepam Intensol, Zetran
Synonyms: n.a.
In the course of checking the drug compatibility and interactions, data from the following reference sources was used: Drugs.com, Rxlist.com, Webmd.com, Medscape.com.
- Cipro XR-Valium injection
- Cipro XR-Valproate
- Cipro XR-Valproate Injection
- Cipro XR-Valproate sodium Intravenous
- Cipro XR-Valproic acid
- Cipro XR-Valproic Acid and Derivatives
- Valium-Ciprofloxacin
- Valium-Ciprofloxacin (Systemic)
- Valium-Ciprofloxacin Extended-Release Tablets
- Valium-Ciprofloxacin in 5% Dextrose
- Valium-Ciprofloxacin injection
- Valium-Ciprofloxacin Injection Concentrate