Ciprofloxacin Extended-Release Tablets and Melphalan Intravenous
Determining the interaction of Ciprofloxacin Extended-Release Tablets and Melphalan Intravenous and the possibility of their joint administration.
In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.
Consumer:Consumer information for this minor interaction is not currently available. Some minor drug interactions may not be clinically relevant in all patients. Minor drug interactions do not usually cause harm or require a change in therapy. However, your healthcare provider can determine if adjustments to your medications are needed.
Professional:Limited data suggest that chemotherapy with antineoplastic agents may reduce the plasma concentrations of oral quinolone antibiotics. The proposed mechanism is decreased quinolone absorption secondary to alteration of intestinal mucosa by cancer chemotherapy. In six patients with newly diagnosed hematologic malignancy, treatment with various antineoplastic agents (cyclophosphamide, cytarabine, daunorubicin, doxorubicin, mitoxantrone, prednisolone, vincristine) decreased the mean peak serum concentration (Cmax) and area under the concentration-time curve (AUC 0 to 4 hours) of ciprofloxacin by approximately 46% each. Data are not available for other quinolone antibiotics.
- Johnson EJ, MacGowan AP, Potter MN, et al "Reduced absorption of oral ciprofloxacin after chemotherapy for haematological malignancy." J Antimicrob Chemother 25 (1990): 837-42
Generic Name: ciprofloxacin
Brand name: Cipro, Cipro XR, Proquin XR, Cipro IV
Synonyms: Ciprofloxacin, Ciprofloxacin (Systemic)
Generic Name: melphalan
Brand name: Alkeran, Alkeran IV, Evomela
Synonyms: Melphalan (oral/injection), Melphalan
In the course of checking the drug compatibility and interactions, data from the following reference sources was used: Drugs.com, Rxlist.com, Webmd.com, Medscape.com.
- Ciprofloxacin Extended-Release Tablets-Melphalan oral/injection
- Ciprofloxacin Extended-Release Tablets-Melphalan Tablets
- Ciprofloxacin Extended-Release Tablets-Memantine
- Ciprofloxacin Extended-Release Tablets-Memantine and Donepezil
- Ciprofloxacin Extended-Release Tablets-Memantine and Donepezil Capsules
- Ciprofloxacin Extended-Release Tablets-Memantine ER capsules
- Melphalan Intravenous-Ciprofloxacin in 5% Dextrose
- Melphalan Intravenous-Ciprofloxacin injection
- Melphalan Intravenous-Ciprofloxacin Injection Concentrate
- Melphalan Intravenous-Ciprofloxacin Intravenous
- Melphalan Intravenous-Ciprofloxacin Oral Suspension
- Melphalan Intravenous-Ciprofloxacin Tablets