Ciprofloxacin Extended-Release Tablets and Targretin (Bexarotene (Systemic))
Determining the interaction of Ciprofloxacin Extended-Release Tablets and Targretin (Bexarotene (Systemic)) and the possibility of their joint administration.
In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.
Consumer:Consumer information for this minor interaction is not currently available. Some minor drug interactions may not be clinically relevant in all patients. Minor drug interactions do not usually cause harm or require a change in therapy. However, your healthcare provider can determine if adjustments to your medications are needed.
Professional:Coadministration with inhibitors of CYP450 3A4 may theoretically increase the plasma concentrations of bexarotene. In vitro studies suggest that bexarotene is metabolized by CYP450 3A4. However, concomitant administration with multiple doses of ketoconazole, a potent CYP450 3A4 inhibitor, did not alter bexarotene plasma concentrations, which would imply that bexarotene elimination is not substantially dependent on CYP450 3A4 metabolism in vivo. Conversely, bexarotene appears to be an inducer of CYP450 3A4 and may reduce the plasma concentrations of CYP450 3A4 inhibitors that are also substrates of the isoenzyme, such as azole antifungals, macrolides, some calcium channel blockers, mifepristone, and nefazodone. The clinical significance is unknown.
- "Product Information. Targretin (bexarotene)" Ligand Pharmaceuticals, San Diego, CA.
Generic Name: ciprofloxacin
Brand name: Cipro, Cipro XR, Proquin XR, Cipro IV
Synonyms: Ciprofloxacin, Ciprofloxacin (Systemic)
Generic Name: bexarotene
Brand name: Targretin
Synonyms: Bexarotene, Bexarotene (Systemic)
In the course of checking the drug compatibility and interactions, data from the following reference sources was used: Drugs.com, Rxlist.com, Webmd.com, Medscape.com.
- Ciprofloxacin Extended-Release Tablets-Targretin (Bexarotene (Topical))
- Ciprofloxacin Extended-Release Tablets-Targretin Gel
- Ciprofloxacin Extended-Release Tablets-Targretin topical
- Ciprofloxacin Extended-Release Tablets-Tarina 24 Fe
- Ciprofloxacin Extended-Release Tablets-Tarina Fe 1/20
- Ciprofloxacin Extended-Release Tablets-Tarka
- Targretin (Bexarotene (Systemic))-Ciprofloxacin in 5% Dextrose
- Targretin (Bexarotene (Systemic))-Ciprofloxacin injection
- Targretin (Bexarotene (Systemic))-Ciprofloxacin Injection Concentrate
- Targretin (Bexarotene (Systemic))-Ciprofloxacin Intravenous
- Targretin (Bexarotene (Systemic))-Ciprofloxacin Oral Suspension
- Targretin (Bexarotene (Systemic))-Ciprofloxacin Tablets