Ciprofloxacin injection and Zyprexa Relprevv
Determining the interaction of Ciprofloxacin injection and Zyprexa Relprevv and the possibility of their joint administration.
In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.
Consumer:Consumer information for this minor interaction is not currently available. Some minor drug interactions may not be clinically relevant in all patients. Minor drug interactions do not usually cause harm or require a change in therapy. However, your healthcare provider can determine if adjustments to your medications are needed.
Professional:Ciprofloxacin may increase olanzapine plasma concentrations. The proposed mechanism is inhibition of hepatic CYP450 1A2 which is partially responsible for the metabolism of olanzapine. A case report noted a doubling of the olanzapine plasma concentration following administration of ciprofloxacin. No adverse effects were observed. Correlation between increased olanzapine plasma concentrations and side effects or response has not been determined. Other fluoroquinolones with a similar metabolic profile may also affect olanzapine. Clinical monitoring of patient tolerance and response, including laboratory olanzapine serum concentrations, is recommended.
- Markowitz JS, DeVane CL "Suspected ciprofloxacin inhibition of olanzapine resulting in increased plasma concentration." J Clin Psychopharmacol 19 (1999): 289-91
Generic Name: ciprofloxacin
Brand name: Cipro, Cipro XR, Proquin XR, Cipro IV
Synonyms: Ciprofloxacin, Ciprofloxacin (Systemic)
Generic Name: olanzapine
Brand name: Zyprexa, Zyprexa Relprevv, Zyprexa Zydis, Zyprexa Intramuscular
Synonyms: Zyprexa Relprevv (injection)
In the course of checking the drug compatibility and interactions, data from the following reference sources was used: Drugs.com, Rxlist.com, Webmd.com, Medscape.com.
- Ciprofloxacin injection-Zyprexa Zydis
- Ciprofloxacin injection-Zyrtec
- Ciprofloxacin injection-Zyrtec (Cetirizine Capsules and Tablets)
- Ciprofloxacin injection-Zyrtec (Cetirizine Chewable Tablets)
- Ciprofloxacin injection-Zyrtec (Cetirizine Orally Disintegrating Tablets)
- Ciprofloxacin injection-Zyrtec (Cetirizine Syrup)
- Zyprexa Relprevv-Ciprofloxacin Injection Concentrate
- Zyprexa Relprevv-Ciprofloxacin Intravenous
- Zyprexa Relprevv-Ciprofloxacin Oral Suspension
- Zyprexa Relprevv-Ciprofloxacin Tablets
- Zyprexa Relprevv-Cisapride Suspension
- Zyprexa Relprevv-Cisapride Tablets