Ciprofloxacin Intravenous and Zyprexa Zydis
Determining the interaction of Ciprofloxacin Intravenous and Zyprexa Zydis and the possibility of their joint administration.
In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.
Consumer:Consumer information for this minor interaction is not currently available. Some minor drug interactions may not be clinically relevant in all patients. Minor drug interactions do not usually cause harm or require a change in therapy. However, your healthcare provider can determine if adjustments to your medications are needed.
Professional:Ciprofloxacin may increase olanzapine plasma concentrations. The proposed mechanism is inhibition of hepatic CYP450 1A2 which is partially responsible for the metabolism of olanzapine. A case report noted a doubling of the olanzapine plasma concentration following administration of ciprofloxacin. No adverse effects were observed. Correlation between increased olanzapine plasma concentrations and side effects or response has not been determined. Other fluoroquinolones with a similar metabolic profile may also affect olanzapine. Clinical monitoring of patient tolerance and response, including laboratory olanzapine serum concentrations, is recommended.
- Markowitz JS, DeVane CL "Suspected ciprofloxacin inhibition of olanzapine resulting in increased plasma concentration." J Clin Psychopharmacol 19 (1999): 289-91
Generic Name: ciprofloxacin
Brand name: Cipro, Cipro XR, Proquin XR, Cipro IV
Synonyms: Ciprofloxacin, Ciprofloxacin (Systemic)
Generic Name: olanzapine
Brand name: Zyprexa, Zyprexa Zydis, Zyprexa Intramuscular, Zyprexa Relprevv
Synonyms: n.a.
In the course of checking the drug compatibility and interactions, data from the following reference sources was used: Drugs.com, Rxlist.com, Webmd.com, Medscape.com.
- Ciprofloxacin Intravenous-Zyrtec
- Ciprofloxacin Intravenous-Zyrtec (Cetirizine Capsules and Tablets)
- Ciprofloxacin Intravenous-Zyrtec (Cetirizine Chewable Tablets)
- Ciprofloxacin Intravenous-Zyrtec (Cetirizine Orally Disintegrating Tablets)
- Ciprofloxacin Intravenous-Zyrtec (Cetirizine Syrup)
- Ciprofloxacin Intravenous-Zyrtec Capsule
- Zyprexa Zydis-Ciprofloxacin Oral Suspension
- Zyprexa Zydis-Ciprofloxacin Tablets
- Zyprexa Zydis-Cisapride Suspension
- Zyprexa Zydis-Cisapride Tablets
- Zyprexa Zydis-Cisatracurium
- Zyprexa Zydis-Cisatracurium Besylate