Ciprofloxacin Tablets and Metoprolol Injection
Determining the interaction of Ciprofloxacin Tablets and Metoprolol Injection and the possibility of their joint administration.
In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.
Consumer:Consumer information for this minor interaction is not currently available. Some minor drug interactions may not be clinically relevant in all patients. Minor drug interactions do not usually cause harm or require a change in therapy. However, your healthcare provider can determine if adjustments to your medications are needed.
Professional:The coadministration of ciprofloxacin and metoprolol may result in elevated plasma concentrations of the latter. In seven healthy male subjects, ciprofloxacin (500 mg orally every 12 hours for 5 doses) increased the area under the plasma concentration-time curve (AUC) of a single oral dose of metoprolol (100 mg) by 54% for its less active (+) enantiomer and 29% for its more active (-) enantiomer. The oral clearance of (+) and (-) metoprolol was decreased by 38.5% and 12.5%, respectively. The mechanism by which ciprofloxacin may increase metoprolol plasma concentrations is unknown. Ciprofloxacin has not been shown to inhibit the CYP450 2D6 isoenzyme, which is responsible for the metabolism of metoprolol and several other beta-blockers. Since pharmacodynamic effects were not described in the study, the clinical significance of the interaction is also unclear. Until further data are available, it may be appropriate to monitor patients for potentially increased pharmacologic effects of metoprolol during concomitant therapy with ciprofloxacin. Patients should be advised to notify their physician if they experience possible symptoms of increased beta blockade such as fainting, swelling of the extremities, weight gain, or slow pulse.
- Waite NM, Rutledge DR, Warbasse LH, Edwards DJ "Disposition of the (+) and (-) isomers of metoprolol following ciprofloxacin treatment." Pharmacotherapy 10 (1990): 236
Generic Name: ciprofloxacin
Brand name: Cipro, Cipro XR, Proquin XR, Cipro IV
Synonyms: Ciprofloxacin, Ciprofloxacin (Systemic)
Generic Name: metoprolol
Brand name: Kapspargo Sprinkle, Lopressor, Toprol-XL, Toprol XL
Synonyms: Metoprolol
In the course of checking the drug compatibility and interactions, data from the following reference sources was used: Drugs.com, Rxlist.com, Webmd.com, Medscape.com.
- Ciprofloxacin Tablets-Metoprolol Intravenous
- Ciprofloxacin Tablets-Metoprolol Succinate
- Ciprofloxacin Tablets-Metoprolol Succinate ER Capsules
- Ciprofloxacin Tablets-Metoprolol Succinate ER Tablets
- Ciprofloxacin Tablets-Metoprolol Tablets
- Ciprofloxacin Tablets-Metoprolol Tartrate
- Metoprolol Injection-Cisapride Suspension
- Metoprolol Injection-Cisapride Tablets
- Metoprolol Injection-Cisatracurium
- Metoprolol Injection-Cisatracurium Besylate
- Metoprolol Injection-Cisatracurium Besylate Injection
- Metoprolol Injection-Cisatracurium besylate Intravenous