Cisapride Suspension and Sunmark Acid Reducer Ranitidine
Determining the interaction of Cisapride Suspension and Sunmark Acid Reducer Ranitidine and the possibility of their joint administration.
In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.
Consumer:Consumer information for this minor interaction is not currently available. Some minor drug interactions may not be clinically relevant in all patients. Minor drug interactions do not usually cause harm or require a change in therapy. However, your healthcare provider can determine if adjustments to your medications are needed.
Professional:During coadministration, cisapride may accelerate but slightly decrease the extent of gastrointestinal absorption of ranitidine. These effects are thought to be secondary to the increased gastrointestinal transit induced by cisapride. In twelve healthy volunteers given cisapride (10 mg single dose) and ranitidine (150 mg single dose), median time to reach peak plasma concentration (Tmax) of ranitidine was one hour less than when ranitidine was taken alone, and area under the concentration-time curve (AUC) was decreased by 24%. Theoretically, the reduced Tmax may translate to a quicker onset of action of ranitidine. The reduction in bioavailability is unlikely to be of clinical significance during regular administration, although the duration of action of a single dose of oral ranitidine may be shortened.
- Rowbotham DJ, Milligan K, McHugh P "Effect of single doses of cisapride and ranitidine administered simultaneously on plasma concentrations of cisapride and ranitidine." Br J Anaesth 67 (1991): 302-5
Generic Name: cisapride
Brand name: Propulsid
Synonyms: Cisapride Tablets
Generic Name: ranitidine
Brand name: Zantac
Synonyms: Ranitidine
In the course of checking the drug compatibility and interactions, data from the following reference sources was used: Drugs.com, Rxlist.com, Webmd.com, Medscape.com.
- Cisapride Suspension-Sunmark All Day Allergy-D
- Cisapride Suspension-Sunmark Anti-Diarrheal
- Cisapride Suspension-Sunmark Anti-Diarrheal Tablet
- Cisapride Suspension-SunMark ClearLax
- Cisapride Suspension-Sunmark Hour Allergy Relief
- Cisapride Suspension-Sunmark Ibuprofen Cold and Sinus
- Sunmark Acid Reducer Ranitidine-Cisapride Tablets
- Sunmark Acid Reducer Ranitidine-Cisatracurium
- Sunmark Acid Reducer Ranitidine-Cisatracurium Besylate
- Sunmark Acid Reducer Ranitidine-Cisatracurium Besylate Injection
- Sunmark Acid Reducer Ranitidine-Cisatracurium besylate Intravenous
- Sunmark Acid Reducer Ranitidine-Cisplatin