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Cisapride Tablets and Xenleta (Lefamulin Tablets)

Determining the interaction of Cisapride Tablets and Xenleta (Lefamulin Tablets) and the possibility of their joint administration.

Check result:

Cisapride Tablets <> Xenleta (Lefamulin Tablets)

Relevance: 25.11.2022 Reviewer: Shkutko P.M., M.D., in

In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.

Consumer:

Consumer information for this interaction is not currently available.CONTRAINDICATED: Cisapride can cause dose-related prolongation of the QT interval. Theoretically, coadministration with other agents that can prolong the QT interval may result in additive effects and increased risk of ventricular arrhythmias including torsade de pointes and sudden death. MANAGEMENT: Coadministration of cisapride with other drugs that can prolong the QT interval is considered contraindicated. References Cerner Multum, Inc. "Australian Product Information." O 0 Michalets EL, Williams CR "Drug interactions with cisapride: clinical implications." Clin Pharmacokinet 39 (2000): 49-75 "Product Information. Propulsid (cisapride)." Janssen Pharmaceutica, Titusville, NJ. Trinkle R "Comment: syncopal episodes associated with cisapride." Ann Pharmacother 33 (1999): 251 Cerner Multum, Inc. "UK Summary of Product Characteristics." O 0 Canadian Pharmacists Association "e-CPS. Available from: URL: http://www.pharmacists.ca/function/Subscriptions/ecps.cfm?link=eCPS_quikLink." View all 6 references

Professional:

CONTRAINDICATED: Cisapride can cause dose-related prolongation of the QT interval. Theoretically, coadministration with other agents that can prolong the QT interval may result in additive effects and increased risk of ventricular arrhythmias including torsade de pointes and sudden death.

MANAGEMENT: Coadministration of cisapride with other drugs that can prolong the QT interval is considered contraindicated.

References

Cerner Multum, Inc. "Australian Product Information." O 0
Michalets EL, Williams CR "Drug interactions with cisapride: clinical implications." Clin Pharmacokinet 39 (2000): 49-75
"Product Information. Propulsid (cisapride)." Janssen Pharmaceutica, Titusville, NJ.
Trinkle R "Comment: syncopal episodes associated with cisapride." Ann Pharmacother 33 (1999): 251
Cerner Multum, Inc. "UK Summary of Product Characteristics." O 0
Canadian Pharmacists Association "e-CPS. Available from: URL: http://www.pharmacists.ca/function/Subscriptions/ecps.cfm?link=eCPS_quikLink."

Cisapride Tablets

Generic Name: cisapride

Brand name: Propulsid

Synonyms: n.a.

What is Cisapride Tablets?

Xenleta (Lefamulin Tablets)

Generic Name: lefamulin

Brand name: Xenleta

Synonyms: Xenleta (Lefamulin Injection), Xenleta, Xenleta (oral/injection)

What is Xenleta (Lefamulin Tablets)?

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In the course of checking the drug compatibility and interactions, data from the following reference sources was used: Drugs.com, Rxlist.com, Webmd.com, Medscape.com.

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