Cisatracurium Besylate and Reglan

• Generic Name: cisatracurium
• Dosage Forms: n.a.
• Other Brand Names: Nimbex

Production of skeletal muscle relaxation during surgery after general anesthesia has been induced.

Facilitation of endotracheal intubation; however, a neuromuscular blocking agent with a rapid onset of action (e.g., succinylcholine, rocuronium) generally preferred in emergency situations when rapid intubation is required. Cisatracurium is not recommended for rapid sequence intubation because of its intermediate onset of action.

Also has been used to facilitate mechanical ventilation in the ICU. Has been given as a continuous IV infusion for up to 6 days in this setting. Whenever neuromuscular blocking agents are used in the ICU, consider benefits versus risks of such therapy and assess patients frequently to determine need for continued paralysis. (See Intensive Care Setting under Cautions.)

Compared with other neuromuscular blocking agents, cisatracurium has an intermediate onset and duration of action; exhibits minimal, if any, cardiovascular effects; and causes less histamine release than atracurium. Because elimination is not dependent on renal or hepatic pathways, may be particularly useful in patients with hepatic or renal dysfunction.

• Generic Name: metoclopramide
• Dosage Forms: injection, solution
• Other Brand Names: Reglan, Metozolv ODT

Reglan (metoclopramide) increases muscle contractions in the upper digestive tract. This speeds up the rate at which the stomach empties into the intestines and may help with nausea.

Reglan is used for 4 to 12 weeks to treat heartburn caused by gastroesophageal reflux in people who have used other medications without relief.

Reglan is also used to treat gastroparesis (slow stomach emptying) in people with diabetes, which can cause heartburn and stomach discomfort after meals.

Reglan may also be used for purposes not listed in this medication guide.