Cisatracurium besylate Intravenous and Quinidine Sulfate Tablets
Determining the interaction of Cisatracurium besylate Intravenous and Quinidine Sulfate Tablets and the possibility of their joint administration.
In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.
Consumer:Ask your doctor before using quiNIDine together with cisatracurium. This can increase the effects cisatracurium and cause fainting or lightheadedness, fever, pounding heartbeat, shortness of breath, wheezing, unusual muscle weakness, or tiredness. If your doctor prescribes these medications together, you may need a dose adjustment or special tests to safely use both medications. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.
Professional:GENERALLY AVOID: The pharmacologic effects of nondepolarizing muscle relaxants and quinidine may be additive. The mechanism may be related to depression of the action potential in skeletal muscles and curare-like effects on the neuromuscular junction by quinidine. This combination could result in increased neuromuscular blockade and respiratory depression.
MANAGEMENT: Quinidine should not be administered immediately after surgery. If it is necessary, the patient's vital signs should be closely monitored. Mechanical ventilatory support may be required during coadministration.
- Sher MH, Mathews PA "Recurarization with quinine administration after reversal from anaesthesia." Anaesth Intensive Care 11 (1983): 241-3
- Way WL, Katzung BG, Larson CP "Recurarization with quinidine." JAMA 200 (1967): 163-4
Generic Name: cisatracurium
Brand name: Nimbex
Synonyms: Cisatracurium
Generic Name: quinidine
Brand name: Quin-G, Cardioquin, Quinora, Quinidex Extentabs, Quinaglute Dura-Tabs, Quin-Release
Synonyms: Quinidine, QuiNIDine
In the course of checking the drug compatibility and interactions, data from the following reference sources was used: Drugs.com, Rxlist.com, Webmd.com, Medscape.com.
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