Cisplatin and Depakote

In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.

Using CISplatin together with divalproex sodium may decrease the effects of divalproex sodium. Contact your doctor if your condition changes or if you experience seizures and other mental status changes. If your doctor does prescribe these medications together, you may need a dose adjustment or special test to safely use both medications. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.

MONITOR: Coadministration with cisplatin may decrease the plasma concentrations and pharmacologic effects of valproic acid. The exact mechanism of interaction is unknown. In one case report, a young woman with a history of epilepsy developed tonic-clonic seizures during antineoplastic therapy with cisplatin and doxorubicin. Anticonvulsant levels were measured during two courses, and lower plasma levels of valproate sodium and carbamazepine were observed after 2 days of antineoplastic therapy. Levels returned to normal 2 to 3 days after the last cisplatin dose. In another report, severe generalized tonic-clonic seizures in association with reduced serum valproate levels developed in a 34-year-old epileptic patient receiving cisplatin-based chemotherapy for the treatment of a testicular tumor. The seizures occurred 7 weeks after the first chemotherapeutic cycle, which consisted of bleomycin and etoposide in addition to cisplatin. Serum valproate concentration was about 50% of what it had been prior to chemotherapy. The patient received the second cycle following recovery of valproate levels and again experienced seizures several days later. Phenytoin 100 mg three times a day was added, but the seizures continued frequently during subsequent cycles in association with markedly reduced serum valproate levels. After four cycles, the chemotherapeutic regimen was changed to paclitaxel, ifosfamide, and cisplatin. However, serum valproate levels remained low, and seizures were observed with each of the two cycles. In contrast, these regimens had no effect on the serum concentrations of phenytoin, which remained in the therapeutic range throughout.

MANAGEMENT: Serum valproate levels should be monitored more closely during therapy with cisplatin. Dosage adjustments may be required.

Cisplatin

Generic Name: cisplatin

Brand name: Platinol, Platinol-AQ

Synonyms: CISplatin

What is Cisplatin?

Depakote

Generic Name: divalproex sodium

Brand name: Depakene, Depacon, Depakote ER, Depakote Sprinkles, Depakote

Synonyms: n.a.

What is Depakote?