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Cisplatin and Ethacrynic Sodium Injection

Determining the interaction of Cisplatin and Ethacrynic Sodium Injection and the possibility of their joint administration.

Check result:

Cisplatin <> Ethacrynic Sodium Injection

Relevance: 14.12.2022 Reviewer: Shkutko P.M., M.D., in

In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.

Consumer:

CISplatin can cause kidney damage and hearing loss, and combining it with ethacrynic acid may increase the risk. These effects may be more likely to occur in older adults or those with preexisting kidney problems or dehydration, or when high dosages of one or both medications are used. Talk to your doctor if you have any questions or concerns. Your doctor may already be aware of the risks, but has determined that this is the best course of treatment for you and has taken appropriate precautions and is monitoring you closely for any potential complications. Keep yourself hydrated by drinking plenty of fluids unless otherwise directed. Let your doctor know if you experience ringing in the ears or hearing loss, or signs and symptoms that may suggest kidney damage such as nausea, vomiting, loss of appetite, increased or decreased urination, sudden weight gain or weight loss, fluid retention, swelling, shortness of breath, muscle cramps, tiredness, weakness, dizziness, confusion, and irregular heart rhythm. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.

Professional:

GENERALLY AVOID: The concomitant use of loop diuretics with cisplatin may increase the risk of ototoxicity. Loop diuretics, especially ethacrynic acid and high doses of furosemide, and cisplatin have been individually associated with ototoxicity.

MANAGEMENT: This combination should be avoided unless the potential benefit outweighs the risk. Audiometric testing is recommended if these drugs are given concurrently. Patients should be advised to promptly notify their physician if they experience hearing loss or tinnitus.

References

Rhodes T, Twentyman PR "A study of ethacrynic acid as a potential modifier of melphalan and cisplatin sensitivity in human lung cancer parental and drug-resistant cell lines." Br J Cancer 65 (1992): 684-90
Parsons SK, Neault MW, Lehmann, et al "Severe ototoxicity following carboplatin-containing conditioning regimen for autologous marrow transplantation for neuroblastoma." Bone Marrow Transplant 22 (1998): 669-74
Brock PR, Knight KR, Freyer DR, et al. "Platinum-induced ototoxicity in children: a consensus review on mechanisms, predisposition, and protection, including a new International Society of Pediatric Oncology Boston ototoxicity scale." J Clin Oncol 30 (2012): 2408-17
Komune S, Snow JB "Potentiating effects of cisplatin and ethacrynic acid in ototoxicity." Arch Otolaryngol 107 (1981): 594-7
"Product Information. Edecrin (ethacrynic acid)." Merck & Co, Inc, West Point, PA.
Langer T, am Zehnhoff-Dinnesen A, Radtke S, Meitert J, Zolk O "Understanding platinum-induced ototoxicity." Trends Pharmacol Sci 34 (2013): 458-69

Cisplatin

Generic Name: cisplatin

Brand name: Platinol, Platinol-AQ

Synonyms: CISplatin

What is Cisplatin?

Ethacrynic Sodium Injection

Generic Name: ethacrynic acid

Brand name: Edecrin, Edecrin Sodium, Sodium Edecrin

Synonyms: Ethacrynic acid, Ethacrynic Acid

What is Ethacrynic Sodium Injection?

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In the course of checking the drug compatibility and interactions, data from the following reference sources was used: Drugs.com, Rxlist.com, Webmd.com, Medscape.com.

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