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Cisplatin and Ifosfamide and Mesna Injection

Determining the interaction of Cisplatin and Ifosfamide and Mesna Injection and the possibility of their joint administration.

Check result:

Cisplatin <> Ifosfamide and Mesna Injection

Relevance: 14.12.2022 Reviewer: Shkutko P.M., M.D., in

In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.

Consumer:

Using CISplatin together with ifosfamide may cause damage to the ears. Contact your doctor if you experience hearing loss or ringing in the ears. If your doctor does prescribe these medications together, you may need a dose adjustment or special test to safely use both medications. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.

Professional:

MONITOR: Limited data suggest that ifosfamide can exacerbate ototoxicity caused by cisplatin. The mechanism is not known.

MANAGEMENT: Some experts recommend serial audiograms for patients receiving both drugs.

References

Meyer WH, Ayers D, McHaney VA, Roberson P, Pratt CB "Ifosfamide and exacerbation of cisplatin-induced hearing loss." Lancet 341 (1993): 754-5

Cisplatin

Generic Name: cisplatin

Brand name: Platinol, Platinol-AQ

Synonyms: CISplatin

What is Cisplatin?

Ifosfamide and Mesna Injection

Generic Name: ifosfamide / mesna

Brand name:

Synonyms: n.a.

What is Ifosfamide and Mesna Injection?

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In the course of checking the drug compatibility and interactions, data from the following reference sources was used: Drugs.com, Rxlist.com, Webmd.com, Medscape.com.

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