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Cisplatin Intravenous and Gemzar

Determining the interaction of Cisplatin Intravenous and Gemzar and the possibility of their joint administration.

Check result:

Cisplatin Intravenous <> Gemzar

Relevance: 04.09.2022 Reviewer: Shkutko P.M., M.D., in

In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.

Consumer:

Consumer information for this minor interaction is not currently available. Some minor drug interactions may not be clinically relevant in all patients. Minor drug interactions do not usually cause harm or require a change in therapy. However, your healthcare provider can determine if adjustments to your medications are needed.

Professional:

In vitro and clinical studies have shown concurrent use of gemcitabine and cisplatin to have a synergistic effect. The precise mechanism of the interaction is unknown. The clearance of cisplatin is reduced during combination use. The clinical implications of these findings are unknown. Caution for increases in toxicity may be appropriate.

References

"Product Information. Gemzar (gemcitabine)." Lilly, Eli and Company, Indianapolis, IN.
Nakamura H, Yamaji Y, Fujita T, Fujita J, Takahara J "Synergistic growth inhibition of gemcitabine/cisplatin, and gemcitabine/etoposide on a human lung cancer cell line, RERF-LC-OK (Meeting abstract)." Proc Annu Meet Am Assoc Cancer Res 36 (1995): a24251995
Peters GJ, Bergman AM, Ruiz van Haperen VW, Veerman G, Kuiper CM, Braakhuis BJ "Interaction between cisplatin and gemcitabine in vitro and in vivo." Semin Oncol 22 (4 supp (1995): 72-9

Cisplatin Intravenous

Generic Name: cisplatin

Brand name: Platinol, Platinol-AQ

Synonyms: Cisplatin, CISplatin

What is Cisplatin Intravenous?

Gemzar

Generic Name: gemcitabine

Brand name: Gemzar, Infugem

Synonyms: n.a.

What is Gemzar?

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In the course of checking the drug compatibility and interactions, data from the following reference sources was used: Drugs.com, Rxlist.com, Webmd.com, Medscape.com.

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