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Citalopram Capsules and Pimozide

Determining the interaction of Citalopram Capsules and Pimozide and the possibility of their joint administration.

Check result:

Citalopram Capsules <> Pimozide

Relevance: 04.12.2022 Reviewer: Shkutko P.M., M.D., in

In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.

Consumer:

Using pimozide together with citalopram is not recommended. Combining these medications can increase the risk of an irregular heart rhythm that may be serious. You should seek immediate medical attention if you develop sudden dizziness, lightheadedness, fainting, or fast or pounding heartbeats during treatment with pimozide. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.

Professional:

CONTRAINDICATED: Coadministration with citalopram has been shown to potentiate the effects of pimozide on the QT interval. The mechanism of interaction is unknown. In a controlled study of healthy young adults, administration of pimozide (2 mg single dose) in combination with citalopram (40 mg once daily for 11 days) was associated with a mean increase in QTc values of approximately 10 msec compared to pimozide given alone. The QTc increase occurred in the absence of a clinically significant pharmacokinetic interaction, as pimozide peak plasma concentration (Cmax) and systemic exposure (AUC) were not substantially or consistently altered during citalopram coadministration. Although not reported in the study, excessive prolongation of the QT interval is associated with ventricular arrhythmias such as ventricular tachycardia and torsade de pointes and sudden death.

MANAGEMENT: The use of pimozide in combination with citalopram or escitalopram is considered contraindicated.

References

"Product Information. Orap Tablets (pimozide)." Gate Pharmaceuticals, Sellersville, PA.
Pharmaceutical Society of Australia "APPGuide online. Australian prescription products guide online. Available from: URL: http://www.appco.com.au/appguide/default.asp." ([2006]):
Cerner Multum, Inc. "UK Summary of Product Characteristics." O 0
Cerner Multum, Inc. "Australian Product Information." O 0
"Product Information. Lexapro (escitalopram)." Forest Pharmaceuticals, St. Louis, MO.
"Product Information. Celexa (citalopram)." Forest Pharmaceuticals, St. Louis, MO.
Canadian Pharmacists Association "e-CPS. Available from: URL: http://www.pharmacists.ca/function/Subscriptions/ecps.cfm?link=eCPS_quikLink."

Citalopram Capsules

Generic Name: citalopram

Brand name: Celexa

Synonyms: Citalopram

What is Citalopram Capsules?

Pimozide

Generic Name: pimozide

Brand name: Orap

Synonyms: n.a.

What is Pimozide?

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In the course of checking the drug compatibility and interactions, data from the following reference sources was used: Drugs.com, Rxlist.com, Webmd.com, Medscape.com.

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