Citicoline and Sinemet

In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.

Consumer information for this minor interaction is not currently available. Some minor drug interactions may not be clinically relevant in all patients. Minor drug interactions do not usually cause harm or require a change in therapy. However, your healthcare provider can determine if adjustments to your medications are needed.

Citicoline may enhance the effects of levodopa. The exact mechanism is unknown, but animal models suggest that citicoline may increase dopamine levels in the brain and/or improve dopaminergic cell survival. In patients with Parkinson's disease, a few studies have demonstrated levodopa-saving effects, whereby the addition of citicoline (500 to 1200 mg/day) allowed for lower dosages of levodopa to be used with stable or improved therapeutic efficacy and reduced side effects in some patients. However, data are limited.

Citicoline

Generic Name: citicoline

Brand name:

Synonyms: n.a.

What is Citicoline?

Sinemet

Generic Name: carbidopa / levodopa

Brand name: Parcopa, Rytary, Sinemet, Sinemet CR, Duopa

Synonyms: n.a.

What is Sinemet?