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Citric acid and potassium citrate and Tolazamide

Determining the interaction of Citric acid and potassium citrate and Tolazamide and the possibility of their joint administration.

Check result:

Citric acid and potassium citrate <> Tolazamide

Relevance: 07.12.2022 Reviewer: Shkutko P.M., M.D., in

In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.

Consumer:

Consumer information for this minor interaction is not currently available. Some minor drug interactions may not be clinically relevant in all patients. Minor drug interactions do not usually cause harm or require a change in therapy. However, your healthcare provider can determine if adjustments to your medications are needed.

Professional:

Alkalinization of the urine may increase the renal clearance of some sulfonylureas for which renal elimination is pH dependent. The clinical significance of this interaction is unknown. Management consists of monitoring blood glucose frequently during the initial period of coadministration. The sulfonylurea dosage should be adjusted as needed and appropriate.

References

Kivisto KT, Neuvonen PJ "Differential effects of sodium bicarbonate and aluminium hydroxide on the absorption and activity of glipizide." Eur J Clin Pharmacol 40 (1991): 383-6
Neuvonen PJ, Karkkainen S "Effects of charcoal, sodium bicarbonate, and ammonium chloride on chlorpropamide kinetics." Clin Pharmacol Ther 33 (1983): 386-93

Citric acid and potassium citrate

Generic Name: citric acid / potassium citrate

Brand name: Cytra-K, Poly-Citra K Crystals, Polycitra-K, Virtrate-K

Synonyms: Potassium Citrate-Citric Acid Crystals

What is Citric acid and potassium citrate?

Tolazamide

Generic Name: tolazamide

Brand name: Tolinase

Synonyms: TOLAZamide

What is Tolazamide?

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In the course of checking the drug compatibility and interactions, data from the following reference sources was used: Drugs.com, Rxlist.com, Webmd.com, Medscape.com.

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