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Citric Acid, Magnesium Carbonate, and Glucono-Delta-Lactone and Nitrofurantoin Macrocrystals

Determining the interaction of Citric Acid, Magnesium Carbonate, and Glucono-Delta-Lactone and Nitrofurantoin Macrocrystals and the possibility of their joint administration.

Check result:
Citric Acid, Magnesium Carbonate, and Glucono-Delta-Lactone <> Nitrofurantoin Macrocrystals
Relevance: 15.06.2022 Reviewer: Shkutko P.M., M.D., in

In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.

Consumer:

Consumer information for this minor interaction is not currently available. Some minor drug interactions may not be clinically relevant in all patients. Minor drug interactions do not usually cause harm or require a change in therapy. However, your healthcare provider can determine if adjustments to your medications are needed.

Professional:

The absorption of nitrofurantoin may be inhibited by magnesium-containing antacids. If a magnesium-containing product must be taken, administration of these agents should be separated by 2 to 3 hours.

References
  • Naggar VF, Khalil SA "Effect of magnesium trisilicate on nitrofurantoin absorption." Clin Pharmacol Ther 25 (1979): 857-63
Citric Acid, Magnesium Carbonate, and Glucono-Delta-Lactone

Generic Name: citric acid / glucono-delta-lactone / magnesium carbonate topical

Brand name: Renacidin

Synonyms: n.a.

Nitrofurantoin Macrocrystals

Generic Name: nitrofurantoin

Brand name: Furadantin, Macrobid, Macrodantin, Nitro Macro

Synonyms: Nitrofurantoin

In the course of checking the drug compatibility and interactions, data from the following reference sources was used: Drugs.com, Rxlist.com, Webmd.com, Medscape.com.