Citric acid, magnesium oxide, and sodium picosulfate and Zyvox (Linezolid Injection)

In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.

The laxative effect of sodium picosulfate may be decreased when used during or following treatment with linezolid. Your doctor may prescribe a substitute for sodium picosulfate that is not affected by treatment with linezolid. You should let your doctor know if you experience signs and symptoms of low magnesium or potassium blood level such as weakness, tiredness, drowsiness, dizziness, confusion, tingling, numbness, muscle pain, cramps, nausea, or vomiting. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.

GENERALLY AVOID: Theoretically, use of sodium picosulfate during or following antibiotic treatment may result in a reduced laxative effect of sodium picosulfate. The proposed mechanism involves antibiotic-induced reduction of colonic bacteria that hydrolyze sodium picosulfate, a prodrug, to its active metabolite bis-(p-hydroxyphenyl)-pyridyl-2-methane (BHPM), a compound that stimulates colonic peristalsis. The clinical significance of this effect remains unknown.

MANAGEMENT: Consider use of an alternate laxative in patients who have recently taken or are currently taking an antibiotic. If concomitant use is required, additional bowel cleansing and colonoscopy may be required.

Citric acid, magnesium oxide, and sodium picosulfate

Generic Name: citric acid / magnesium oxide / sodium picosulfate

Brand name: Clenpiq, Prepopik

Synonyms: n.a.

What is Citric acid, magnesium oxide, and sodium picosulfate?

Zyvox (Linezolid Injection)

Generic Name: linezolid

Brand name: Zyvox

Synonyms: Zyvox

What is Zyvox (Linezolid Injection)?