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Cladribine Intravenous and Cytarabine liposome Intrathecal

Determining the interaction of Cladribine Intravenous and Cytarabine liposome Intrathecal and the possibility of their joint administration.

Check result:

Cladribine Intravenous <> Cytarabine liposome Intrathecal

Relevance: 14.09.2022 Reviewer: Shkutko P.M., M.D., in

In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.

Consumer:

Consumer information for this interaction is not currently available.GENERALLY AVOID: The use of cladribine with medications that undergo intracellular phosphorylation may reduce its efficacy by inhibiting its phosphorylation to its active form. The clinical significance of this interaction is unknown. MANAGEMENT: Concomitant use of cladribine with medications that undergo intracellular phosphorylation should be avoided if possible. References EMEA. European Medicines Agency "EPARs. European Union Public Assessment Reports. Available from: URL: http://www.ema.europa.eu/ema/index.jsp?curl=pages/includes/medicines/medicines_landingpage.jsp&mid." Cerner Multum, Inc. "UK Summary of Product Characteristics." O 0 "Product Information. Leustatin (cladribine)." Ortho Biotech Inc, Raritan, NJ.

Professional:

GENERALLY AVOID: The use of cladribine with medications that undergo intracellular phosphorylation may reduce its efficacy by inhibiting its phosphorylation to its active form. The clinical significance of this interaction is unknown.

MANAGEMENT: Concomitant use of cladribine with medications that undergo intracellular phosphorylation should be avoided if possible.

References

EMEA. European Medicines Agency "EPARs. European Union Public Assessment Reports. Available from: URL: http://www.ema.europa.eu/ema/index.jsp?curl=pages/includes/medicines/medicines_landingpage.jsp&mid."
Cerner Multum, Inc. "UK Summary of Product Characteristics." O 0
"Product Information. Leustatin (cladribine)." Ortho Biotech Inc, Raritan, NJ.

Cladribine Intravenous

Generic Name: cladribine

Brand name: Mavenclad, Leustatin

Synonyms: Cladribine

What is Cladribine Intravenous?

Cytarabine liposome Intrathecal

Generic Name: cytarabine liposomal

Brand name: DepoCyt

Synonyms: Cytarabine (Liposomal)

What is Cytarabine liposome Intrathecal?

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In the course of checking the drug compatibility and interactions, data from the following reference sources was used: Drugs.com, Rxlist.com, Webmd.com, Medscape.com.

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