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Cladribine (oral) and Plegridy Pen Starter Pack

Determining the interaction of Cladribine (oral) and Plegridy Pen Starter Pack and the possibility of their joint administration.

Check result:

Cladribine (oral) <> Plegridy Pen Starter Pack

Relevance: 05.10.2022 Reviewer: Shkutko P.M., M.D., in

In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.

Consumer:

Consumer information for this interaction is not currently available.GENERALLY AVOID: The use of cladribine with beta interferons may increase the risk of lymphopenia. The mechanism involves additive risk of lymphopenia. In a phase 2 study of patients experiencing active relapsing multiple sclerosis, lymphopenia was reported significantly more in patients who received interferon-beta and cladribine (40.3%) versus patients who received interferon-beta alone (0%). MANAGEMENT: Concomitant use of cladribine and beta interferons is not recommended. References Cerner Multum, Inc. "UK Summary of Product Characteristics." O 0 Montalban X, Leist TP, Cohen BA, et.al "Cladribine tablets added to IFN-â in active relapsing MS: The ONWARD study." Neurol Neruroimmunol Neuroinflamm 11 (2018): e477 "Product Information. Leustatin (cladribine)." Ortho Biotech Inc, Raritan, NJ. Cerner Multum, Inc. "Australian Product Information." O 0 View all 4 references

Professional:

GENERALLY AVOID: The use of cladribine with beta interferons may increase the risk of lymphopenia. The mechanism involves additive risk of lymphopenia. In a phase 2 study of patients experiencing active relapsing multiple sclerosis, lymphopenia was reported significantly more in patients who received interferon-beta and cladribine (40.3%) versus patients who received interferon-beta alone (0%).

MANAGEMENT: Concomitant use of cladribine and beta interferons is not recommended.

References

Cerner Multum, Inc. "UK Summary of Product Characteristics." O 0
Montalban X, Leist TP, Cohen BA, et.al "Cladribine tablets added to IFN-â in active relapsing MS: The ONWARD study." Neurol Neruroimmunol Neuroinflamm 11 (2018): e477
"Product Information. Leustatin (cladribine)." Ortho Biotech Inc, Raritan, NJ.
Cerner Multum, Inc. "Australian Product Information." O 0

Cladribine (oral)

Generic Name: cladribine

Brand name: Mavenclad, Leustatin

Synonyms: Cladribine

What is Cladribine (oral)?

Plegridy Pen Starter Pack

Generic Name: peginterferon beta-1a

Brand name: Plegridy, Plegridy Pen, Plegridy Pen Starter Pack, Plegridy Starter Pack

Synonyms: Plegridy

What is Plegridy Pen Starter Pack?

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In the course of checking the drug compatibility and interactions, data from the following reference sources was used: Drugs.com, Rxlist.com, Webmd.com, Medscape.com.

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