Cladribine Tablets and Cobicistat, darunavir, emtricitabine, and tenofovir
Determining the interaction of Cladribine Tablets and Cobicistat, darunavir, emtricitabine, and tenofovir and the possibility of their joint administration.
In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.
Consumer:Talk to your doctor before using cladribine together with tenofovir. Some investigators have suggested that medications like tenofovir may reduce the effectiveness of cladribine, although this has not been studied extensively. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.
Professional:GENERALLY AVOID: The use of cladribine with medications that undergo intracellular phosphorylation may reduce its efficacy by inhibiting its phosphorylation to its active form. The clinical significance of this interaction is unknown.
MANAGEMENT: Concomitant use of cladribine with medications that undergo intracellular phosphorylation should be avoided if possible.
- EMEA. European Medicines Agency "EPARs. European Union Public Assessment Reports. Available from: URL: http://www.ema.europa.eu/ema/index.jsp?curl=pages/includes/medicines/medicines_landingpage.jsp&mid."
- Cerner Multum, Inc. "UK Summary of Product Characteristics." O 0
- "Product Information. Leustatin (cladribine)." Ortho Biotech Inc, Raritan, NJ.
Generic Name: cladribine
Brand name: Mavenclad, Leustatin
Synonyms: Cladribine
Generic Name: cobicistat / darunavir / emtricitabine / tenofovir alafenamide
Brand name: Symtuza
Synonyms: Darunavir, Cobicistat, Emtricitabine, and Tenofovir Alafenamide
In the course of checking the drug compatibility and interactions, data from the following reference sources was used: Drugs.com, Rxlist.com, Webmd.com, Medscape.com.
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