Clarithromycin Oral Suspension and Esomeprazole Delayed-Release Tablets
Determining the interaction of Clarithromycin Oral Suspension and Esomeprazole Delayed-Release Tablets and the possibility of their joint administration.
In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.
Consumer:Consumer information for this minor interaction is not currently available. Some minor drug interactions may not be clinically relevant in all patients. Minor drug interactions do not usually cause harm or require a change in therapy. However, your healthcare provider can determine if adjustments to your medications are needed.
Professional:Clarithromycin may increase the plasma concentration of esomeprazole. The mechanism may be related to clarithromycin inhibition of hepatic cytochrome P450 enzymes responsible for esomeprazole metabolism. The systemic exposure (AUC) to esomeprazole doubled after coadministration with clarithromycin 500 mg twice daily. The clinical significance is unknown and dose adjustments are not required.
- Cerner Multum, Inc. "Australian Product Information." O 0
- Cerner Multum, Inc. "UK Summary of Product Characteristics." O 0
Generic Name: clarithromycin
Brand name: Biaxin, Biaxin XL
Synonyms: Clarithromycin
Generic Name: esomeprazole
Brand name: Esomeprazole Strontium, Nexium, Nexium, NexIUM 24HR, Nexium IV
Synonyms: Esomeprazole
In the course of checking the drug compatibility and interactions, data from the following reference sources was used: Drugs.com, Rxlist.com, Webmd.com, Medscape.com.
- Clarithromycin Oral Suspension-Esomeprazole injection
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- Clarithromycin Oral Suspension-Esomeprazole Strontium
- Esomeprazole Delayed-Release Tablets-Clarithromycin Suspension
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