Clarithromycin Suspension and Dabigatran Etexilate
Determining the interaction of Clarithromycin Suspension and Dabigatran Etexilate and the possibility of their joint administration.
In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.
Consumer:Consumer information for this minor interaction is not currently available. Some minor drug interactions may not be clinically relevant in all patients. Minor drug interactions do not usually cause harm or require a change in therapy. However, your healthcare provider can determine if adjustments to your medications are needed.
Professional:Coadministration with clarithromycin may slightly increase the bioavailability of dabigatran following oral administration of dabigatran etexilate. The proposed mechanism is clarithromycin inhibition of the P-glycoprotein efflux transporter, of which dabigatran etexilate is a substrate. When dabigatran etexilate was coadministered with clarithromycin 500 mg twice a day in healthy volunteers, increases in dabigatran peak plasma concentration (Cmax) by about 15% and systemic exposure (AUC) by about 19% were observed without any clinical safety concern. Dabigatran had no significant effect on the pharmacokinetics of clarithromycin. No dosage adjustment for dabigatran etexilate is recommended during coadministration with clarithromycin, but caution may be advisable.
- "Product Information. Pradaxa (dabigatran)." Boehringer-Ingelheim, Ridgefield, CT.
- Cerner Multum, Inc. "Australian Product Information." O 0
- "Product Information. Pradax (dabigatran)." Boehringer Ingelheim (Canada) Ltd, Burlington, IA.
- Cerner Multum, Inc. "UK Summary of Product Characteristics." O 0
Generic Name: clarithromycin
Brand name: Biaxin, Biaxin XL
Synonyms: Clarithromycin
Generic Name: dabigatran
Brand name: Pradaxa
Synonyms: Dabigatran
In the course of checking the drug compatibility and interactions, data from the following reference sources was used: Drugs.com, Rxlist.com, Webmd.com, Medscape.com.
- Clarithromycin Suspension-Dabigatran Etexilate Mesylate
- Clarithromycin Suspension-Dabrafenib
- Clarithromycin Suspension-Dabrafenib Mesylate
- Clarithromycin Suspension-Dacarbazine
- Clarithromycin Suspension-Dacarbazine Intravenous, Injection
- Clarithromycin Suspension-Daclatasvir
- Dabigatran Etexilate-Clarithromycin Tablets
- Dabigatran Etexilate-Claritin
- Dabigatran Etexilate-Claritin Liqui-Gels
- Dabigatran Etexilate-Claritin Reditab
- Dabigatran Etexilate-Claritin Reditabs
- Dabigatran Etexilate-Claritin-D