Clarithromycin Tablets and Esomeprazole injection

In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.

Consumer information for this minor interaction is not currently available. Some minor drug interactions may not be clinically relevant in all patients. Minor drug interactions do not usually cause harm or require a change in therapy. However, your healthcare provider can determine if adjustments to your medications are needed.

Clarithromycin may increase the plasma concentration of esomeprazole. The mechanism may be related to clarithromycin inhibition of hepatic cytochrome P450 enzymes responsible for esomeprazole metabolism. The systemic exposure (AUC) to esomeprazole doubled after coadministration with clarithromycin 500 mg twice daily. The clinical significance is unknown and dose adjustments are not required.

Clarithromycin Tablets

Generic Name: clarithromycin

Brand name: Biaxin, Biaxin XL

Synonyms: Clarithromycin

What is Clarithromycin Tablets?

Esomeprazole injection

Generic Name: esomeprazole

Brand name: Esomeprazole Strontium, Nexium, Nexium, NexIUM 24HR, Nexium IV

Synonyms: Esomeprazole

What is Esomeprazole injection?