Clarithromycin Tablets and Zidovudine Intravenous
Determining the interaction of Clarithromycin Tablets and Zidovudine Intravenous and the possibility of their joint administration.
In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.
Consumer:Consumer information for this minor interaction is not currently available. Some minor drug interactions may not be clinically relevant in all patients. Minor drug interactions do not usually cause harm or require a change in therapy. However, your healthcare provider can determine if adjustments to your medications are needed.
Professional:Clarithromycin may alter the rate at which zidovudine is absorbed. Conflicting reports indicate that peak serum zidovudine concentrations may increase or decrease. The proposed mechanism is a change in gastric emptying time induced by clarithromycin. It is recommended that these two agents be administered at least 2 hours apart.
- Gustavson LE, Chu SY, Mackenthun A, Gupta MS, Craft JC "Drug interaction between clarithromycin and oral zidovudine in HIV-1 infected patients." Clin Pharmacol Ther 53 (1993): 163
- Vance E, Watsonbitar M, Gustavson L, Kazanjian P "Pharmacokinetics of clarithromycin and zidovudine in patients with AIDS." Antimicrob Agents Chemother 39 (1995): 1355-60
Generic Name: clarithromycin
Brand name: Biaxin, Biaxin XL
Synonyms: Clarithromycin
Generic Name: zidovudine
Brand name: Retrovir
Synonyms: Zidovudine (oral/injection), Zidovudine
In the course of checking the drug compatibility and interactions, data from the following reference sources was used: Drugs.com, Rxlist.com, Webmd.com, Medscape.com.
- Clarithromycin Tablets-Zidovudine Oral Solution
- Clarithromycin Tablets-Zidovudine oral/injection
- Clarithromycin Tablets-Zidovudine Syrup
- Clarithromycin Tablets-Zidovudine Tablets
- Clarithromycin Tablets-Ziks Arthritis Pain Relief
- Clarithromycin Tablets-Zilactin L
- Zidovudine Intravenous-Claritin
- Zidovudine Intravenous-Claritin Liqui-Gels
- Zidovudine Intravenous-Claritin Reditab
- Zidovudine Intravenous-Claritin Reditabs
- Zidovudine Intravenous-Claritin-D
- Zidovudine Intravenous-Claritin-D 12 Hour