Clevidipine Butyrate and Xultophy

• Generic Name: clevidipine
• Dosage Forms: n.a.
• Other Brand Names: Cleviprex

Used to reduce BP when oral antihypertensive therapy not feasible or desirable.

Calcium-channel blockers considered one of several preferred antihypertensive drug classes for initial management of hypertension; other preferred options include ACE inhibitors, angiotensin II receptor antagonists, and thiazide diuretics.

Clevidipine used for management of perioperative hypertension (e.g., in cardiac surgery), essential hypertension, and severe hypertension (e.g., hypertensive emergencies).

Some experts state that clevidipine is one of the preferred agents for the management of hypertensive emergencies in patients with certain comorbidities such as acute pulmonary edema, acute renal failure, and acute sympathetic discharge or catecholamine excess states (e.g., pheochromocytoma, post-carotid endarterectomy status). (See Pheochromocytoma under Cautions.)

• Generic Name: insulin degludec / liraglutide
• Dosage Forms: injection, solution
• Other Brand Names: Xultophy

Xultophy is an injection pen containing a combination of insulin degludec and liraglutide. Insulin is a hormone that works by lowering levels of glucose (sugar) in the blood. Insulin degludec is a long-acting insulin that starts to work several hours after injection and keeps working evenly for 24 hours. Liraglutide is similar to a hormone that occurs naturally in the body and helps control blood sugar, insulin levels, and digestion.

Xultophy is used to lower blood sugar in adults with type 2 diabetes mellitus. This medicine should be used together with diet and exercise.

Xultophy is usually given when your blood sugar levels have not been well controlled by using other medications.

Xultophy is not for people with type 1 diabetes.