Clidinium and Chlordiazepoxide and Prucalopride Succinate
Determining the interaction of Clidinium and Chlordiazepoxide and Prucalopride Succinate and the possibility of their joint administration.
In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.
Consumer:Clidinium may reduce the effects of prucalopride in the treatment of chronic constipation. Contact your doctor if your symptoms worsen or your condition changes during treatment with these medications. Your doctor may be able to prescribe alternatives that do not interact, or you may need a dose adjustment or more frequent monitoring to safely use both medications. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.
Professional:MONITOR: Concomitant administration of anticholinergic agents would be expected to reduce the therapeutic effects of prucalopride. Prucalopride increases bowel motility by stimulating colonic peristalsis (high-amplitude propagating contractions), an action that has been shown to be facilitated by acetylcholine release in isolated gastrointestinal tissues from various animal species.
MANAGEMENT: Monitoring for altered efficacy of prucalopride may be advisable during concomitant use with anticholinergic agents.
- EMEA. European Medicines Agency "EPARs. European Union Public Assessment Reports. Available from: URL: http://www.ema.europa.eu/ema/index.jsp?curl=pages/includes/medicines/medicines_landingpage.jsp&mid."
- "Product Information. Resotran (prucalopride)." Janssen Pharmaceuticals, Titusville, NJ.
Generic Name: chlordiazepoxide / clidinium
Brand name: Librax, Clindex, Chlordinium
Synonyms: Chlordiazepoxide and clidinium, Chlordiazepoxide and Clidinium Capsules
Generic Name: prucalopride
Brand name: Motegrity
Synonyms: Prucalopride
In the course of checking the drug compatibility and interactions, data from the following reference sources was used: Drugs.com, Rxlist.com, Webmd.com, Medscape.com.
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