Climara Pro and Pitolisant
Determining the interaction of Climara Pro and Pitolisant and the possibility of their joint administration.
In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.
Consumer:Consumer information for this interaction is not currently available.ADDITIONAL CONTRACEPTION RECOMMENDED: Coadministration with pitolisant may decrease the plasma concentrations of contraceptive hormones. The proposed mechanism is induction of the CYP450 3A4-mediated metabolism of estrogens and progestins by pitolisant and its main metabolites. MANAGEMENT: The manufacturer recommends that alternative, nonhormonal methods of effective contraception should be used during and for at least 21 days after pitolisant therapy. References "Product Information. Wakix (pitolisant)." Harmony Biosciences, LLC, Plymouth Meeting, PA. Cerner Multum, Inc. "UK Summary of Product Characteristics." O 0 Faculty of Sexual & Reproductive Healthcare "FSRH Clinical Guidance: Drug Interactions with Hormonal Contraception. Available from: URL: file:///C:/Users/df033684/Downloads/ceuguidancedruginteractionshormonal.pdf." ([2012, Jan 1]):
Professional:ADDITIONAL CONTRACEPTION RECOMMENDED: Coadministration with pitolisant may decrease the plasma concentrations of contraceptive hormones. The proposed mechanism is induction of the CYP450 3A4-mediated metabolism of estrogens and progestins by pitolisant and its main metabolites.
MANAGEMENT: The manufacturer recommends that alternative, nonhormonal methods of effective contraception should be used during and for at least 21 days after pitolisant therapy.
- "Product Information. Wakix (pitolisant)." Harmony Biosciences, LLC, Plymouth Meeting, PA.
- Cerner Multum, Inc. "UK Summary of Product Characteristics." O 0
- Faculty of Sexual & Reproductive Healthcare "FSRH Clinical Guidance: Drug Interactions with Hormonal Contraception. Available from: URL: file:///C:/Users/df033684/Downloads/ceuguidancedruginteractionshormonal.pdf." ([2012, Jan 1]):
Generic Name: estradiol / levonorgestrel
Brand name: Climara Pro
Synonyms: n.a.
In the course of checking the drug compatibility and interactions, data from the following reference sources was used: Drugs.com, Rxlist.com, Webmd.com, Medscape.com.
- Climara Pro-Pitolisant Hydrochloride
- Climara Pro-Pitressin
- Climara Pro-Pitressin Injection
- Climara Pro-Pitressin Synthetic
- Climara Pro-Placidyl
- Climara Pro-Plan B
- Pitolisant-Climara Pro transdermal
- Pitolisant-Climara Transdermal
- Pitolisant-CLIN Single Use Kit
- Pitolisant-Clinac BPO 7
- Pitolisant-Clinacort
- Pitolisant-Clinda-Derm