Clindamycin Palmitate Hydrochloride Granules and Verapamil Hydrochloride PM
Determining the interaction of Clindamycin Palmitate Hydrochloride Granules and Verapamil Hydrochloride PM and the possibility of their joint administration.
In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.
Consumer:Before taking clindamycin, tell your doctor if you also use verapamil. You may need dose adjustments or special tests in order to safely take both medications together. Taking these medications together may increase the effects of verapamil. It is important that you tell your healthcare provider about all other medications that you are using including vitamins and herbs. Do not stop using your medications without first talking to your doctor first.
Professional:MONITOR: According to a single case report, when ceftriaxone and clindamycin were added to the regimen of a patient who was receiving a stable dosage of verapamil and other medications, acute verapamil toxicity resulted. The patient developed complete heart block. The mechanism is unknown and causality was not clearly determined. The purported mechanism (displacement of verapamil from protein binding sites) has been disputed.
MANAGEMENT: Until more information is available, patients should be monitored for verapamil toxicity.
- Kishore K, Raina A, Misra V, Jonas E "Acute verapamil toxicity in a patient with chronic toxicity: possible interaction with ceftriaxone and clindamycin." Ann Pharmacother 27 (1993): 877-80
Generic Name: clindamycin
Brand name: Cleocin HCl, Cleocin Pediatric, Cleocin Phosphate, Cleocin Phosphate ADD-Vantage, Clindesse, ClindaMax Vaginal, Cleocin
Synonyms: Clindamycin, Clindamycin (Systemic)
Generic Name: verapamil
Brand name: Calan, Isoptin SR, Verelan, Isoptin, Calan SR, Isoptin IV, Covera-HS, Verelan PM
Synonyms: Verapamil
In the course of checking the drug compatibility and interactions, data from the following reference sources was used: Drugs.com, Rxlist.com, Webmd.com, Medscape.com.
- Clindamycin Palmitate Hydrochloride Granules-Verapamil Immediate-Release Tablets
- Clindamycin Palmitate Hydrochloride Granules-Verapamil Injection
- Clindamycin Palmitate Hydrochloride Granules-Verapamil Intravenous
- Clindamycin Palmitate Hydrochloride Granules-Verapamil Long-Acting Capsules
- Clindamycin Palmitate Hydrochloride Granules-Verapamil Long-Acting Tablets
- Clindamycin Palmitate Hydrochloride Granules-Verapamil oral/injection
- Verapamil Hydrochloride PM-Clindamycin Phosphate
- Verapamil Hydrochloride PM-Clindamycin Phosphate and Benzoyl Peroxide
- Verapamil Hydrochloride PM-Clindamycin Phosphate topical
- Verapamil Hydrochloride PM-Clindamycin Pledget
- Verapamil Hydrochloride PM-Clindamycin Solution and Swab
- Verapamil Hydrochloride PM-Clindamycin topical