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Clinoril and Dimethyl sulfoxide

Determining the interaction of Clinoril and Dimethyl sulfoxide and the possibility of their joint administration.

Check result:

Clinoril <> Dimethyl sulfoxide

Relevance: 28.06.2023 Reviewer: Shkutko P.M., M.D., in

In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.

Consumer:

Ask your doctor before using sulindac together with dimethyl sulfoxide. Using these medications together may cause sulindac to be less effective or cause nerve pain in your extremities. Tell your doctor if you experience dizziness, numbness, skin tingling, or muscle twitching which may be signs of nerve damage. You may need a dose adjustment or special tests to safely use both medications. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.

Professional:

GENERALLY AVOID: Dimethyl sulfoxide (DMSO) may reduce serum concentrations of the active metabolite, sulindac sulfide, by inhibiting sulindac reductase. The therapeutic effect of sulindac may be reduced. In addition, concomitant use of these agents has been reported to cause peripheral neuropathy. The mechanism is unknown.

MANAGEMENT: It may be advisable to avoid this drug combination.

References

Swanson BN, Ferguson RK, Raskin NH, Wolf BA "Peripheral neuropathy after concomitant administration of dimethyl sulfoxide and sulindac." Arthritis Rheum 26 (1983): 791-3
Cerner Multum, Inc. "Australian Product Information." O 0
Reinstein L, Mahon R, Russso GL "Peripheral neuropathy after concomitant dimethyl sulfoxide use and sulindac therapy." Arch Phys Med Rehabil 63 (1982): 581-4
"Product Information. Clinoril (sulindac)." Merck & Co, Inc, West Point, PA.
Swanson BN, Boppana Vk, Vlasses PH, Rotmensch HH, Ferguson RK "Dimethyl sulfoxide inhibits bioactivation of sulindac." J Lab Clin Med 102 (1983): 95-101

Clinoril

Generic Name: sulindac

Brand name: Clinoril

Synonyms: n.a.

What is Clinoril?

Dimethyl sulfoxide

Generic Name: dimethyl sulfoxide

Brand name: Cryoserv, Rimso-50

Synonyms: n.a.

What is Dimethyl sulfoxide?

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In the course of checking the drug compatibility and interactions, data from the following reference sources was used: Drugs.com, Rxlist.com, Webmd.com, Medscape.com.

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