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Clobazam Oral Film and Zovia 1/35e

Determining the interaction of Clobazam Oral Film and Zovia 1/35e and the possibility of their joint administration.

Check result:

Clobazam Oral Film <> Zovia 1/35e

Relevance: 10.09.2022 Reviewer: Shkutko P.M., M.D., in

In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.

Consumer:

CloBAZam may reduce the blood levels and effects of ethinyl estradiol. If you are using birth control pills or another hormone-type contraceptive such as a patch, shot, vaginal ring or implant, you should talk to your doctor before taking cloBAZam. You may need an alternative or additional method of birth control during and for at 28 days after treatment with cloBAZam in order to avoid an unintended pregnancy. Let your doctor know if you experience bleeding outside of your menstrual cycle, since it may indicate reduced effectiveness of ethinyl estradiol. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.

Professional:

ADDITIONAL CONTRACEPTION RECOMMENDED: Coadministration with clobazam, a weak inducer of CYP450 3A4, may decrease the plasma concentrations of contraceptive hormones.

MANAGEMENT: Women using hormonal contraceptives should be advised of the risk of breakthrough bleeding and unintended pregnancy during concomitant therapy with clobazam. Additional, nonhormonal forms of contraception should be used during and for 28 days after discontinuing clobazam treatment to ensure contraceptive reliability. A significant interaction with hormone-releasing intrauterine systems is not anticipated due to their local action. Injectable progestin-only contraceptives are also thought to be unaffected by enzyme-inducing drugs. Input from a gynecologist or similar expert on adequate contraception, including emergency contraception, should be sought as needed.

References

"Product Information. Onfi (clobazam)." Lundbeck Inc, Deerfield, IL.
Faculty of Sexual & Reproductive Healthcare "FSRH Clinical Guidance: Drug Interactions with Hormonal Contraception. Available from: URL: file:///C:/Users/df033684/Downloads/ceuguidancedruginteractionshormonal.pdf." ([2012, Jan 1]):

Clobazam Oral Film

Generic Name: clobazam

Brand name: Onfi, Sympazan

Synonyms: Clobazam

What is Clobazam Oral Film?

Zovia 1/35e

Generic Name: ethinyl estradiol / ethynodiol

Brand name: Kelnor, Zovia 1/35, Zovia 1/50, Demulen 1/35, Demulen 1/50, Zovia 1/35e, Kelnor 1/50, Kelnor 1/35, Zovia 1/50e

Synonyms: Zovia 1/35, Zovia 1/35E

What is Zovia 1/35e?

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In the course of checking the drug compatibility and interactions, data from the following reference sources was used: Drugs.com, Rxlist.com, Webmd.com, Medscape.com.

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