Clobetasol Cream,Ointment and Telotristat Etiprate

• Generic Name: clobetasol topical
• Dosage Forms: cream, ointment, gel
• Other Brand Names: Clobex, Clodan, Cormax, Impoyz, Olux, Olux-E, Temovate, Temovate E, Embeline E, Clobevate, Embeline, Olux/Olux-E Kit, Cormax Scalp, Tovet

Clobetasol is a highly potent steroid that helps reduce inflammation in the body.

Clobetasol topical (for the skin) is used to treat inflammation and itching caused by plaque psoriasis or skin conditions that respond to steroid medication.

Clobetasol topical may also be used for purposes not listed in this medication guide.

• Generic Name: telotristat
• Dosage Forms: n.a.
• Other Brand Names: Xermelo

Used (in combination with somatostatin analog therapy) for treatment of carcinoid syndrome diarrhea inadequately controlled by somatostatin analog therapy alone (designated an orphan drug by FDA for the treatment of carcinoid syndrome in patients with neuroendocrine tumors).

Carcinoid syndrome, a condition associated with serotonin overproduction, is characterized by flushing, diarrhea, wheezing, occasionally congestive heart failure, and various other manifestations. Although somatostatin analogs (e.g., octreotide, lanreotide) are standard treatment for carcinoid syndrome and are effective initially in most patients, some patients may not respond adequately or may develop recurrent symptoms, including diarrhea, despite therapy.

In clinical studies, telotristat ethyl reduced the frequency of daily bowel movements in patients with carcinoid syndrome diarrhea. Reductions in other symptoms of carcinoid syndrome (e.g., abdominal pain, flushing) not observed.