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Clofibrate and Rifadin IV Intravenous

Determining the interaction of Clofibrate and Rifadin IV Intravenous and the possibility of their joint administration.

Check result:
Clofibrate <> Rifadin IV Intravenous
Relevance: 26.03.2023 Reviewer: Shkutko P.M., M.D., in

In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.

Consumer:

Consumer information for this minor interaction is not currently available. Some minor drug interactions may not be clinically relevant in all patients. Minor drug interactions do not usually cause harm or require a change in therapy. However, your healthcare provider can determine if adjustments to your medications are needed.

Professional:

Rifampin may increase the metabolism of clofibrate. Serum concentration and therapeutic efficacy of clofibrate may be reduced. Theoretically, a similar reaction may occur with rifabutin, although data are lacking. Higher dosages of clofibrate may be required to sustain an adequate lipid-lowering effect, and more frequent monitoring of serum levels may be needed.

References
  • Houin G, Tillement JP "Clofibrate and enzymatic induction in man." Int J Clin Pharmacol 16 (1978): 150-4
Clofibrate

Generic Name: clofibrate

Brand name:

Synonyms: Clofibrate (Oral)

Rifadin IV Intravenous

Generic Name: rifampin

Brand name: Rifadin IV, Rifadin, Rimactane

Synonyms: Rifadin IV (Intravenous), Rifadin IV

In the course of checking the drug compatibility and interactions, data from the following reference sources was used: Drugs.com, Rxlist.com, Webmd.com, Medscape.com.

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