Clomiphene Citrate and Valbenazine Tosylate

• Generic Name: clomiphene
• Dosage Forms: n.a.
• Other Brand Names: Clomid, Serophene

Used to induce ovulation in appropriately selected anovulatory women desiring pregnancy in whom ovulatory dysfunction has been demonstrated.

Optimum results obtained in patients with adequately functioning anterior pituitary gland, adrenals, ovaries, and thyroid, including women with polycystic ovary syndrome, amenorrhea-galactorrhea syndrome, psychogenic amenorrhea, post-oral-contraceptive amenorrhea, and certain cases of secondary amenorrhea of unknown etiology. Better results usually obtained in patients with adequate serum estrogen concentrations; however, reduced serum estrogen concentrations do not always preclude successful therapy.

Use recommended only in women who are not pregnant, without ovarian cysts or ovarian enlargement (unless enlargement is due to polycystic ovarian syndrome), with normal liver function, and with no abnormal vaginal bleeding.

Ineffective in patients with primary pituitary or ovarian failure; not a substitute for appropriate therapy of other conditions that may cause ovulatory dysfunction (e.g., thyroid or adrenal disease).

Manufacturer states that clomiphene is not recommended to induce ovulation associated with in vitro fertilization programs.

• Generic Name: valbenazine
• Dosage Forms: n.a.
• Other Brand Names: Ingrezza

Treatment of tardive dyskinesia.

Tardive dyskinesia is a hyperkinetic movement disorder associated with prolonged use of antipsychotic agents or other antidopaminergic drugs (e.g., metoclopramide).

Prior to the availability of valbenazine, there was no standard treatment for tardive dyskinesia. Management generally included discontinuance or reducing the dosage of the precipitating drug when possible, switching from a conventional or first-generation antipsychotic to an atypical or second-generation antipsychotic, or switching to clozapine therapy.