Clomipramine Capsules and Nitroglycerin Sublingual Tablets
Determining the interaction of Clomipramine Capsules and Nitroglycerin Sublingual Tablets and the possibility of their joint administration.
In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.
Consumer:Nitroglycerin and clomiPRAMINE may have additive effects in lowering your blood pressure. You may experience headache, dizziness, lightheadedness, fainting, and/or changes in pulse or heart rate. These side effects are most likely to be seen at the beginning of treatment, following a dose increase, or when treatment is restarted after an interruption. Let your doctor know if you develop these symptoms and they do not go away after a few days or they become troublesome. Avoid driving or operating hazardous machinery until you know how the medications affect you, and use caution when getting up from a sitting or lying position. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.
Professional:MONITOR: Many psychotherapeutic and CNS-active agents (e.g., anxiolytics, sedatives, hypnotics, antidepressants, antipsychotics, opioids, alcohol, muscle relaxants) exhibit hypotensive effects, especially during initiation of therapy and dose escalation. Coadministration with antihypertensives and other hypotensive agents, in particular vasodilators and alpha-blockers, may result in additive effects on blood pressure and orthostasis.
MANAGEMENT: Caution is advised during coadministration of these agents. Close monitoring for development of hypotension is recommended. Patients should be advised to avoid rising abruptly from a sitting or recumbent position and to notify their physician if they experience dizziness, lightheadedness, syncope, orthostasis, or tachycardia.
- Feder R "Bradycardia and syncope induced by fluoxetine." J Clin Psychiatry 52 (1991): 139
- Ellison JM, Milofsky JE, Ely E "Fluoxetine-induced bradycardia and syncope in two patients." J Clin Psychiatry 51 (1990): 385-6
- Sternbach H "Fluoxetine-associated potentiation of calcium-channel blockers." J Clin Psychopharmacol 11 (1991): 390-1
- Rodriguez de la Torre B, Dreher J, Malevany I, et al. "Serum levels and cardiovascular effects of tricyclic antidepressants and selective serotonin reuptake inhibitors in depressed patients." Ther Drug Monit 23 (2001): 435-40
- Pacher P, Kecskemeti V "Cardiovascular side effects of new antidepressants and antipsychotics: new drugs, old concerns?" Curr Pharm Des 10 (2004): 2463-75
- Andrews C, Pinner G "Postural hypotension induced by paroxetine." BMJ 316 (1998): 595
Generic Name: clomipramine
Brand name: Anafranil
Synonyms: Clomipramine, ClomiPRAMINE
Generic Name: nitroglycerin
Brand name: Gonitro, Nitrolingual, NitroMist, Nitrostat, Nitro-Time, Gonitro, Minitran, Nitro TD Patch-A, Nitro-Dur, Nitro-Bid, Nitrol Appli-Kit, Rectiv
Synonyms: Nitroglycerin (oral/sublingual), Nitroglycerin
In the course of checking the drug compatibility and interactions, data from the following reference sources was used: Drugs.com, Rxlist.com, Webmd.com, Medscape.com.
- Clomipramine Capsules-Nitroglycerin topical
- Clomipramine Capsules-Nitroglycerin transdermal
- Clomipramine Capsules-Nitroglycerin Transdermal Patch
- Clomipramine Capsules-Nitrol Appli-Kit topical
- Clomipramine Capsules-Nitrolingual
- Clomipramine Capsules-Nitrolingual Pumpspray
- Nitroglycerin Sublingual Tablets-Clomipramine Hydrochloride
- Nitroglycerin Sublingual Tablets-Clonazepam
- Nitroglycerin Sublingual Tablets-Clonazepam Orally Disintegrating Tablets
- Nitroglycerin Sublingual Tablets-Clonazepam Tablet Orally Disintegrating
- Nitroglycerin Sublingual Tablets-Clonazepam Tablets
- Nitroglycerin Sublingual Tablets-Clonidine