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Clomipramine Hydrochloride and Concerta

Determining the interaction of Clomipramine Hydrochloride and Concerta and the possibility of their joint administration.

Check result:

Clomipramine Hydrochloride <> Concerta

Relevance: 26.12.2022 Reviewer: Shkutko P.M., M.D., in

In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.

Consumer:

Before taking clomiPRAMINE, tell your doctor if you also use methylphenidate. You may need dose adjustments or special tests in order to safely take both medications together. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using your medications without first talking to your doctor first.

Professional:

MONITOR: The coadministration with methylphenidate may increase the serum concentrations of tricyclic antidepressants (TCAs). Case reports involving primarily methylphenidate and imipramine have suggested favorable as well as unfavorable clinical effects from this combination. In vitro studies suggest that methylphenidate may inhibit the metabolism of imipramine and other TCAs, although the extent is probably subject to considerable interindividual variation.

MANAGEMENT: Pharmacologic response to TCAs should be monitored more closely whenever methylphenidate (racemic) or dexmethylphenidate (the more pharmacologically active d-enantiomer) is added to or withdrawn from therapy, and the TCA dosage adjusted as necessary.

References

Gwirtsman HE, Szuba MP, Toren L, Feist M "The antidepressant response to tricyclics in major depressives is accelerated with adjunctive use of methylphenidate." Psychopharmacol Bull 30 (1994): 157-64
Grob CS, Coyle JT "Suspected adverse methylphenidate-imipramine interactions in children." J Dev Behav Pediatr 7 (1986): 265-7
Meyers B "Treatment of imipramine-resistant depression and lithium-refractory mania through drug interactions." Am J Psychiatry 135 (1978): 1420-1
Cooper TB, Simpson GM "Concomitant imipramine and methylphenidate administration: a case report." Am J Psychiatry 130 (1973): 721
Zeidenberg P, Perel JM, Kanzler M, Wharton RN, Malitz S "Clinical and metabolic studies with imipramine in man." Am J Psychiatry 127 (1971): 1321-6
Burke MS, Josephson A, Lightsey A "Combined methylphenidate and imipramine complication." J Am Acad Child Adolesc Psychiatry 34 (1995): 403-4
Wharton RN, Perel JM, Dayton PG, Malitz S "A potential clinical use for methylphenidate with tricyclic antidepressants." Am J Psychiatry 127 (1971): 1619-25

Clomipramine Hydrochloride

Generic Name: clomipramine

Brand name: Anafranil

Synonyms: Clomipramine, ClomiPRAMINE

What is Clomipramine Hydrochloride?

Concerta

Generic Name: methylphenidate

Brand name: Aptensio XR, Concerta, Cotempla XR-ODT, Jornay PM, Metadate CD, Metadate ER, Methylin, QuilliChew ER, Quillivant XR, Ritalin, Ritalin LA, Ritalin SR, Adhansia XR, Relexxii, Daytrana, Methylin ER

Synonyms: n.a.

What is Concerta?

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In the course of checking the drug compatibility and interactions, data from the following reference sources was used: Drugs.com, Rxlist.com, Webmd.com, Medscape.com.

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