Clomipramine Hydrochloride and Verapamil Hydrochloride PM
Determining the interaction of Clomipramine Hydrochloride and Verapamil Hydrochloride PM and the possibility of their joint administration.
In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.
Consumer:Before taking verapamil, tell your doctor if you also use clomiPRAMINE. You may need dose adjustments or special tests in order to safely take both medications together. This combination may increase the effects of clomiPRAMINE. You should notify your doctor if you have symptoms of dry mouth, blurry vision, irregular or fast heartbeat, constipation, urine retention, dizziness, or a drop in blood pressure that is brought on by changes in body position. It is important that you tell your healthcare provider about all other medications that you are using including vitamins and herbs. Do not stop using your medications without first talking to your doctor first.
Professional:MONITOR: Concurrent administration of verapamil may increase tricyclic antidepressant (TCA) serum concentrations. The mechanism appears to be inhibition of CYP450 metabolism. Pharmacologic and toxic effects of TCAs may be increased.
MANAGEMENT: Close monitoring for clinical response and tolerance is recommended whenever verapamil is added to or discontinued from an antidepressant regimen. Patients should be advised to notify their physician if they experience excessive antidepressant effects such as dry mouth, blurry vision, irregular or fast heartbeat, constipation, urinary retention, dizziness, or orthostatic hypotension. Dose adjustments may be necessary.
- Hermann DJ, Krol TF, Dukes GE, et al "Comparison of verapamil, diltiazem, and labetalol on the bioavailability and metabolism of imipramine." J Clin Pharmacol 32 (1992): 176-83
- "Product Information. Calan (verapamil)." Searle, Skokie, IL.
Generic Name: clomipramine
Brand name: Anafranil
Synonyms: Clomipramine, ClomiPRAMINE
Generic Name: verapamil
Brand name: Calan, Isoptin SR, Verelan, Isoptin, Calan SR, Isoptin IV, Covera-HS, Verelan PM
Synonyms: Verapamil
In the course of checking the drug compatibility and interactions, data from the following reference sources was used: Drugs.com, Rxlist.com, Webmd.com, Medscape.com.
- Clomipramine Hydrochloride-Verapamil Immediate-Release Tablets
- Clomipramine Hydrochloride-Verapamil Injection
- Clomipramine Hydrochloride-Verapamil Intravenous
- Clomipramine Hydrochloride-Verapamil Long-Acting Capsules
- Clomipramine Hydrochloride-Verapamil Long-Acting Tablets
- Clomipramine Hydrochloride-Verapamil oral/injection
- Verapamil Hydrochloride PM-Clonazepam
- Verapamil Hydrochloride PM-Clonazepam Orally Disintegrating Tablets
- Verapamil Hydrochloride PM-Clonazepam Tablet Orally Disintegrating
- Verapamil Hydrochloride PM-Clonazepam Tablets
- Verapamil Hydrochloride PM-Clonidine
- Verapamil Hydrochloride PM-Clonidine and Chlorthalidone