Clomipramine Hydrochloride and Ziv-Aflibercept (Systemic)

• Generic Name: clomipramine
• Dosage Forms: n.a.
• Other Brand Names: Anafranil

Among the drugs of choice for the management of OCD.

Reduces but does not completely eliminate obsessions and compulsions.

Has been used effectively for the management of panic disorder with or without agoraphobia.

Has been used effectively for the management of major depressive disorder.

Despite comparable efficacy, the adverse effect profile (e.g., anticholinergic effects) of clomipramine may limit its usefulness relative to other antidepressants (e.g., TCAs, SSRIs).

Effective antidepressant when obsessive manifestations accompany episode of major depressive disorder.

Has been used for the management of chronic pain (e.g., central pain, idiopathic pain disorder, tension headache, diabetic peripheral neuropathy, cancer pain) alone or as adjunct to conventional analgesics.

Has been used for the symptomatic management of cataplexy in a limited number of patients with cataplexy and associated narcolepsy.

Has been used for the management of repetitive and obsessive-compulsive behaviors and hyperactivity associated with autistic disorder; does not treat core symptoms of autistic disorder.

Has been used for the management of trichotillomania (an urge to pull out one’s hair) in a limited number of patients with the disorder; relapse reported in some patients receiving long-term therapy.

Has been used for the management of severe onychophagia (nail biting) without a history of OCD.

Associated with relatively high dropout rate because of adverse effects and drug intolerance; not considered first-line therapy in most patients with onychophagia.

Has been used for the management of anorexia nervosa in a limited number of patients with the disorder.

Initial therapeutic effects (e.g., improved eating behavior, weight gain) not sustained with long-term therapy (e.g., ≥8 weeks).

Avoid use in underweight individuals and in those exhibiting suicidal ideation.

Has been used for the management of premature ejaculation.

Has been used for the management of premenstrual syndrome.

• Generic Name: ziv-aflibercept
• Dosage Forms: n.a.
• Other Brand Names: Zaltrap

• It is used to treat colorectal cancer.