Clonazepam and Sinequan (Doxepin Oral Concentrate)
Determining the interaction of Clonazepam and Sinequan (Doxepin Oral Concentrate) and the possibility of their joint administration.
In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.
Consumer:Using doxepin together with clonazePAM may add to dizziness, drowsiness, breathing problems, and other side effects. This may be more likely to occur in older adults or those with a debilitating condition. Talk with your doctor before using clonazePAM together with doxepin. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.
Professional:MONITOR: Central nervous system- and/or respiratory-depressant effects may be additively or synergistically increased in patients taking clonazepam and tricyclic antidepressants. However, one case report has described decreased desipramine levels during concurrent administration with clonazepam. The mechanism is unknown.
MANAGEMENT: Patients should be monitored for excessive or prolonged CNS and respiratory depression. Ambulatory patients should be made aware of the possibility of additive CNS effects (e.g., drowsiness, dizziness, lightheadedness, or confusion) and counseled to avoid activities requiring alertness until they know how these agents affect them. Patients should also be advised to notify their physician if they experience excessive or prolonged CNS effects that interfere with their normal activities.
- Deicken RF "Clonazepam-induced reduction in serum desipramine concentration." J Clin Psychopharmacol 8 (1988): 71-3
Generic Name: clonazepam
Brand name: Klonopin, Klonopin Wafer
Synonyms: ClonazePAM
Generic Name: doxepin
Brand name: Sinequan, Sinequan, Silenor
Synonyms: Sinequan Capsules, Sinequan
In the course of checking the drug compatibility and interactions, data from the following reference sources was used: Drugs.com, Rxlist.com, Webmd.com, Medscape.com.
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