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Clonazepam Orally Disintegrating Tablets and Luvox CR

Determining the interaction of Clonazepam Orally Disintegrating Tablets and Luvox CR and the possibility of their joint administration.

Check result:
Clonazepam Orally Disintegrating Tablets <> Luvox CR
Relevance: 20.06.2022 Reviewer: Shkutko P.M., M.D., in

In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.

Consumer:

Using clonazePAM together with fluvoxaMINE may increase the effects of clonazePAM. Contact your doctor if you experience extreme drowsiness, confusion, muscle weakness, loss of balance or coordination, feeling light-headed, or fainting. If your doctor does prescribe these medications together, you may need a dose adjustment or special test to safely use both medications. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.

Professional:

MONITOR: Administration of fluvoxamine with certain benzodiazepines may increase CNS depression (e.g., sedation, ataxia). The mechanism appears to be inhibition of the CYP450 3A4 hepatic oxidative metabolism of the benzodiazepine. This interaction has been reported for alprazolam and diazepam, but may also occur with other benzodiazepines.

MANAGEMENT: The patient should be observed for increased CNS depression. Dosage adjustments may be required. Lorazepam, temazepam, and oxazepam, which are not metabolized by oxidative metabolism, may be better alternatives if a benzodiazepine is required.

References
  • Fleishaker JC, Hulst LK "A pharmacokinetic and pharmacodynamic evaluation of the combined administration of alprazolam and fluvoxamine." Eur J Clin Pharmacol 46 (1994): 35-9
  • "Product Information. Luvox (fluvoxamine)." Solvay Pharmaceuticals Inc, Marietta, GA.
  • Vonmoltke LL, Greenblatt DJ, Court MH, Duan SX, Harmatz JS, Shader RI "Inhibition of alprazolam and desipramine hydroxylation in vitro by paroxetine and fluvoxamine: comparison with other selective serotonin reuptake inhibitor antidepressants." J Clin Psychopharmacol 15 (1995): 125-31
Clonazepam Orally Disintegrating Tablets

Generic Name: clonazepam

Brand name: Klonopin, Klonopin Wafer

Synonyms: Clonazepam, ClonazePAM

Luvox CR

Generic Name: fluvoxamine

Brand name: Luvox CR, Luvox

Synonyms: n.a.

In the course of checking the drug compatibility and interactions, data from the following reference sources was used: Drugs.com, Rxlist.com, Webmd.com, Medscape.com.