Clonazepam Tablet Orally Disintegrating and Depakote Capsules
Determining the interaction of Clonazepam Tablet Orally Disintegrating and Depakote Capsules and the possibility of their joint administration.
In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.
Consumer:Before taking clonazePAM, tell your doctor if you also use divalproex sodium. You may need dose adjustments or special tests in order to safely take both medications together. This combination may affect seizure control and cause drowsiness. You should avoid driving until you know how these medications will affect you. It is important that you tell your healthcare provider about all other medications that you are using including vitamins and herbs. Do not stop using your medications without first talking to your doctor first.
Professional:MONITOR: A single study has suggested that combination therapy with clonazepam and valproic acid may cause severe drowsiness and decreased seizure control. Other studies have not supported this finding. Several case reports have suggested that the combination of clonazepam and valproic acid may precipitate absence status; however, this combination has had beneficial effects in the treatment refractory absence seizures. The mechanism and causality have not been determined. In addition, valproic acid may decrease plasma levels of clonazepam by inducing its hepatic metabolism.
MANAGEMENT: Monitoring for altered efficacy and safety is recommended if valproic acid (or its derivatives) and clonazepam are used together. Alternative therapy may be appropriate if significant side effects or loss of seizure control occur.
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- Cerner Multum, Inc. "UK Summary of Product Characteristics." O 0
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- "Product Information. Klonopin (clonazepam)." Roche Laboratories, Nutley, NJ.
Generic Name: clonazepam
Brand name: Klonopin, Klonopin Wafer
Synonyms: Clonazepam, ClonazePAM
Generic Name: divalproex sodium
Brand name: Depakote ER, Depakote Sprinkles, Depakene, Depacon, Depakote
Synonyms: Depakote Sprinkles
In the course of checking the drug compatibility and interactions, data from the following reference sources was used: Drugs.com, Rxlist.com, Webmd.com, Medscape.com.
- Clonazepam Tablet Orally Disintegrating-Depakote DR
- Clonazepam Tablet Orally Disintegrating-Depakote ER
- Clonazepam Tablet Orally Disintegrating-Depakote Pellets
- Clonazepam Tablet Orally Disintegrating-Depakote Sprinkles
- Clonazepam Tablet Orally Disintegrating-Depen
- Clonazepam Tablet Orally Disintegrating-Depen Titratabs
- Depakote Capsules-Clonazepam Tablets
- Depakote Capsules-Clonidine
- Depakote Capsules-Clonidine and Chlorthalidone
- Depakote Capsules-Clonidine Epidural
- Depakote Capsules-Clonidine Epidural Injection
- Depakote Capsules-Clonidine Extended-Release Tablets