Clonazepam Tablet Orally Disintegrating and Probenecid and colchicine
Determining the interaction of Clonazepam Tablet Orally Disintegrating and Probenecid and colchicine and the possibility of their joint administration.
In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.
Consumer:Consumer information for this minor interaction is not currently available. Some minor drug interactions may not be clinically relevant in all patients. Minor drug interactions do not usually cause harm or require a change in therapy. However, your healthcare provider can determine if adjustments to your medications are needed.
Professional:Limited clinical evidence suggests that benzodiazepine effects may have a more rapid onset and be more prolonged when probenecid is used concurrently. The mechanism may be related to interference with hepatic benzodiazepine conjugation. The clinical significance is unknown. Patients should be monitored for prolonged or excessive CNS depression. Benzodiazepine dosage reductions may be necessary.
- Dundee JW, Halliday NJ, McMurray TJ "Aspirin and probenecid pretreatment influences the potency of thiopentone and the onset of action of midazolam." Eur J Anaesthesiol 3 (1986): 247-51
- Abernethy DR, Greenblatt DJ, Ameer B, Shader RI "Probenecid impairment of acetaminophen and lorazepam clearance: direct inhibition of ether glucuronide formation." J Pharmacol Exp Ther 234 (1985): 345-9
Generic Name: clonazepam
Brand name: Klonopin, Klonopin Wafer
Synonyms: Clonazepam, ClonazePAM
Generic Name: colchicine / probenecid
Brand name:
Synonyms: Probenecid and colchicine (Oral)
In the course of checking the drug compatibility and interactions, data from the following reference sources was used: Drugs.com, Rxlist.com, Webmd.com, Medscape.com.
- Clonazepam Tablet Orally Disintegrating-Probenecid Tablets
- Clonazepam Tablet Orally Disintegrating-Probiotic Formula (Bacillus Coagulans)
- Clonazepam Tablet Orally Disintegrating-Probucol
- Clonazepam Tablet Orally Disintegrating-Probuphine
- Clonazepam Tablet Orally Disintegrating-Procainamide
- Clonazepam Tablet Orally Disintegrating-Procainamide capsules
- Probenecid and colchicine-Clonazepam Tablets
- Probenecid and colchicine-Clonidine
- Probenecid and colchicine-Clonidine and Chlorthalidone
- Probenecid and colchicine-Clonidine Epidural
- Probenecid and colchicine-Clonidine Epidural Injection
- Probenecid and colchicine-Clonidine Extended-Release Tablets