Clonazepam Tablets and Phenohytro Elixir
Determining the interaction of Clonazepam Tablets and Phenohytro Elixir and the possibility of their joint administration.
In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.
Consumer:Before taking clonazePAM, tell your doctor if you also use PHENobarbital. You may need dose adjustments or special tests in order to safely take both medications together. If you are already taking this combination you should contact your doctor if you have symptoms of breathing problems, confusion, or altered consciousness. It is important that you tell your healthcare provider about all other medications that you are using including vitamins and herbs. Do not stop using your medications without first talking to your doctor first.
Professional:MONITOR: Barbiturates may increase the plasma clearance of clonazepam and thereby reduce its clinical effectiveness. Phenobarbital is the only barbiturate specifically implicated in this interaction. However, other barbiturates may behave in a similar fashion. Also, clonazepam may increase the effectiveness of barbiturates. A case of respiratory depression and coma has been reported in a patient receiving high doses of both clonazepam and amobarbital.
MANAGEMENT: If these drugs are used together, close observation for altered clonazepam and barbiturate effects is indicated.
- Khoo KC, Mendels J, Rothbart M, et al. "Influence of phenytoin and phenobarbital on the disposition of a single oral dose of clonazepam." Clin Pharmacol Ther 28 (1980): 368-75
- Nanda RN, Johnson RH, Keogh HJ, Lambie DG, Melville ID "Treatment of epilepsy with clonazepam and its effect on other anticonvulsants." J Neurol Neurosurg Psychiatry 40 (1977): 538-43
- Honer WG, Rosenberg RG, Turey M, Fisher WA "Respiratory failure after clonazepam and amobarbital ." Am J Psychiatry 143 (1986): 1495
Generic Name: clonazepam
Brand name: Klonopin, Klonopin Wafer
Synonyms: Clonazepam, ClonazePAM
Generic Name: atropine / hyoscyamine / phenobarbital / scopolamine
Brand name: Donnatal, D-Tal, Phenohytro, Chardonna-2, Hyosophen, Donnapine, Elixiral, Bellatal, Spasmolin, Haponal, Antispas, Barbidonna, Donnatal Extentabs, Antispasmodic, Bellalphen, Donnaphen, Spasquid, Alkabel-SR, Bellatal ER, Servira, PB-Hyos, Quadrapax, Phenobarbital with Belladonna Alkaloids
Synonyms: Phenohytro
In the course of checking the drug compatibility and interactions, data from the following reference sources was used: Drugs.com, Rxlist.com, Webmd.com, Medscape.com.
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