Clonazepam Tablets and Rifampin Oral, Intravenous
Determining the interaction of Clonazepam Tablets and Rifampin Oral, Intravenous and the possibility of their joint administration.
In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.
Consumer:Consumer information for this minor interaction is not currently available. Some minor drug interactions may not be clinically relevant in all patients. Minor drug interactions do not usually cause harm or require a change in therapy. However, your healthcare provider can determine if adjustments to your medications are needed.
Professional:Rifampin may decrease benzodiazepine serum levels. The mechanism is probably related to stimulation of the hepatic metabolism of benzodiazepines. Diazepam and triazolam have been specifically studied in this regard, although other benzodiazepines also may interact with rifampin. Additionally, rifabutin may have an interaction with benzodiazepines similar to that of rifampin.
- Ochs HR, Greenblatt DJ, Roberts GM, Dengler HJ "Diazepam interaction with antituberculosis drugs." Clin Pharmacol Ther 29 (1981): 671-8
- Strayhorn VA, Baciewicz AM, Self TH "Update on rifampin drug interactions, III." Arch Intern Med 157 (1997): 2453-8
- Ochs HR, Greenblatt DJ, Roberts GM, Dengler HJ "Diazepam interaction with antituberculosis drugs." Clin Pharmacol Ther 29 (1981): 671-8
- Villikka K, Kivisto KT, Backman JT, Olkkola KT, Neuvonen PJ "Triazolam is ineffective in patients taking rifampin." Clin Pharmacol Ther 61 (1997): 8-14
Generic Name: clonazepam
Brand name: Klonopin, Klonopin Wafer
Synonyms: Clonazepam, ClonazePAM
Generic Name: rifampin
Brand name: Rifadin, Rifadin IV, Rimactane
Synonyms: Rifampin
In the course of checking the drug compatibility and interactions, data from the following reference sources was used: Drugs.com, Rxlist.com, Webmd.com, Medscape.com.
- Clonazepam Tablets-Rifampin, Isoniazid, and Pyrazinamide
- Clonazepam Tablets-Rifamycin
- Clonazepam Tablets-Rifamycin Sodium
- Clonazepam Tablets-Rifapentine
- Clonazepam Tablets-Rifater
- Clonazepam Tablets-Rifaximin
- Rifampin Oral, Intravenous-Clonidine
- Rifampin Oral, Intravenous-Clonidine and Chlorthalidone
- Rifampin Oral, Intravenous-Clonidine Epidural
- Rifampin Oral, Intravenous-Clonidine Epidural Injection
- Rifampin Oral, Intravenous-Clonidine Extended-Release Tablets
- Rifampin Oral, Intravenous-Clonidine injection