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Clonidine and Chlorthalidone and Silenor

Determining the interaction of Clonidine and Chlorthalidone and Silenor and the possibility of their joint administration.

Check result:

Clonidine and Chlorthalidone <> Silenor

Relevance: 22.07.2022 Reviewer: Shkutko P.M., M.D., in

In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.

Consumer:

Talk to your doctor before using cloNIDine and doxepin. This combination may cause nausea, vomiting, sweating, flushing, dizziness, stiff neck, headache or heart palpitations. If you take both medications together, tell your doctor if you have any of these symptoms. You may need a dose adjustment or need your blood pressure checked more often. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.

Professional:

GENERALLY AVOID: Potentially life-threatening elevations in blood pressure have been observed when tricyclic antidepressants (TCAs) and clonidine have been administered concomitantly. The mechanism is postulated to be enhancement of the pressor response by the TCA. Reports are available for clomipramine, desipramine and imipramine.

MANAGEMENT: It is recommended that this combination be avoided. If no alternatives exist and this combination must be used, blood pressure should be monitored closely, especially during the first few weeks of therapy. When clonidine, the TCA, or the combination is discontinued, gradual withdrawal is recommended to prevent abrupt blood pressure fluctuations. Patients should be advised to seek medical help if they develop potential symptoms of a hypertensive crisis such as nausea, vomiting, sweating, flushing, dizziness, stiff neck, headache or palpitations.

References

Stiff JL, Harris DB "Clonidine withdrawal complicated by amitriptyline therapy." Anesthesiology 59 (1983): 73-4
Elliott HL, McLean K, Sumner DJ, Reid JL "Absence of an effect of mianserin on the actions of clonidine or methyldopa in hypertensive patients." Eur J Clin Pharmacol 24 (1983): 15-9
Checkley SA, Slade AP, Shur E, Dawling S "A pilot study of the mechanism of action of desipramine." Br J Psychiatry 138 (1981): 248-51
Gundert-Remy U, Amann E, Hildebrandt R, Weber E "Lack of interaction between the tetracyclic antidepressant maprotiline and the centrally acting antihypertensive drug clonidine." Eur J Clin Pharmacol 25 (1983): 595-9
Gilman AG, Rall TW, Nies AS, Taylor P, eds. "Goodman and Gilman's the Pharmacological Basis of Therapeutics. 8th ed." New York, NY: Pergamon Press Inc. (1990):
Elliott HL, Whiting B, Reid JL "Assessment of the interaction between mianserin and centrally-acting antihypertensive drugs." Br J Clin Pharmacol 15 (1983): s323-8

Clonidine and Chlorthalidone

Generic Name: chlorthalidone / clonidine

Brand name: Clorpres

Synonyms: n.a.

What is Clonidine and Chlorthalidone?

Silenor

Generic Name: doxepin

Brand name: Silenor, Sinequan, Sinequan

Synonyms: n.a.

What is Silenor?

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In the course of checking the drug compatibility and interactions, data from the following reference sources was used: Drugs.com, Rxlist.com, Webmd.com, Medscape.com.

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