Clonidine Epidural Injection and Hydrochlorothiazide and methyldopa
Determining the interaction of Clonidine Epidural Injection and Hydrochlorothiazide and methyldopa and the possibility of their joint administration.
In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.
Consumer:Talk to your doctor before using cloNIDine together with methyldopa. Combining these medications may cause excessive slowing of your heart rate that can lead to serious or life-threatening cardiac complications. Contact your doctor if you develop dizziness, lightheadedness, fainting, shortness of breath, chest pain, or heart palpitations during treatment with these medications. You may need a dose adjustment or more frequent monitoring by your doctor to safely use both medications. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.
Professional:MONITOR: Coadministration of clonidine with other sympatholytic drugs may produce additive effects on the sinus and atrioventricular (AV) nodes, potentially causing sinus node dysfunction and AV block. There have been postmarketing reports of patients with conduction abnormalities and/or concomitant use of other sympatholytic drugs who developed severe bradycardia while taking clonidine. Intravenous atropine, isoproterenol, and temporary cardiac pacing were required in some cases.
MANAGEMENT: Close clinical monitoring of hemodynamic response and tolerance is recommended if clonidine is prescribed with other sympatholytic drugs, and the dosage(s) adjusted as necessary.
- "Product Information. Catapres (clonidine)." Boehringer-Ingelheim, Ridgefield, CT.
Generic Name: clonidine
Brand name: Catapres, Kapvay, Catapres-TTS, Duraclon, Catapres-TTS-1, Catapres-TTS-2, Catapres-TTS-3
Synonyms: Clonidine, CloNIDine
Generic Name: hydrochlorothiazide / methyldopa
Brand name: Aldoril 15, Aldoril 25, Aldoril D30, Aldoril D50
Synonyms: Methyldopa and Hydrochlorothiazide
In the course of checking the drug compatibility and interactions, data from the following reference sources was used: Drugs.com, Rxlist.com, Webmd.com, Medscape.com.
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