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Clonidine Extended-Release Tablets and Lidocaine injection

Determining the interaction of Clonidine Extended-Release Tablets and Lidocaine injection and the possibility of their joint administration.

Check result:

Clonidine Extended-Release Tablets <> Lidocaine injection

Relevance: 07.06.2023 Reviewer: Shkutko P.M., M.D., in

In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.

Consumer:

Consumer information for this minor interaction is not currently available. Some minor drug interactions may not be clinically relevant in all patients. Minor drug interactions do not usually cause harm or require a change in therapy. However, your healthcare provider can determine if adjustments to your medications are needed.

Professional:

Clonidine prolongs the duration of lidocaine anesthesia in peripheral and central neuraxial blocks. Data have been conflicting as to whether the mechanism is pharmacokinetic or pharmacodynamic.

References

Kopacz DJ, Bernards CM "Effect of Clonidine on Lidocaine Clearance In Vivo: A Microdialysis Study in Humans." Anesthesiology 95 (2001): 1371-1376
Inomata S, Tanaka E, Miyabe M, et al. "Plasma Lidocaine Concentrations During Continuous Thoracic Epidural Anesthesia After Clonidine Premedication in Children." Anesth Analg 93 (2001): 1147-1151

Clonidine Extended-Release Tablets

Generic Name: clonidine

Brand name: Catapres, Kapvay, Catapres-TTS, Duraclon, Catapres-TTS-1, Catapres-TTS-2, Catapres-TTS-3

Synonyms: Clonidine, CloNIDine

What is Clonidine Extended-Release Tablets?

Lidocaine injection

Generic Name: lidocaine

Brand name: UAD Caine, Xylocaine HCl, Xylocaine-MPF, Lidoject 1, Xylocaine Dental Cartridges, Lidoject 2, Xylocaine Duo-Trach Kit, Xylocaine HCl For Spinal, L-Caine, Dilocaine, Nervocaine, Truxacaine, Anestacaine

Synonyms: Lidocaine (Systemic)

What is Lidocaine injection?

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In the course of checking the drug compatibility and interactions, data from the following reference sources was used: Drugs.com, Rxlist.com, Webmd.com, Medscape.com.

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