Clonidine Oral, Transdermal and Lidocaine Topical Oral Solution 4%
Determining the interaction of Clonidine Oral, Transdermal and Lidocaine Topical Oral Solution 4% and the possibility of their joint administration.
In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.
Consumer:Consumer information for this minor interaction is not currently available. Some minor drug interactions may not be clinically relevant in all patients. Minor drug interactions do not usually cause harm or require a change in therapy. However, your healthcare provider can determine if adjustments to your medications are needed.
Professional:Clonidine prolongs the duration of lidocaine anesthesia in peripheral and central neuraxial blocks. Data have been conflicting as to whether the mechanism is pharmacokinetic or pharmacodynamic.
- Kopacz DJ, Bernards CM "Effect of Clonidine on Lidocaine Clearance In Vivo: A Microdialysis Study in Humans." Anesthesiology 95 (2001): 1371-1376
- Inomata S, Tanaka E, Miyabe M, et al. "Plasma Lidocaine Concentrations During Continuous Thoracic Epidural Anesthesia After Clonidine Premedication in Children." Anesth Analg 93 (2001): 1147-1151
Generic Name: clonidine
Brand name: Catapres, Kapvay, Catapres-TTS, Duraclon, Catapres-TTS-1, Catapres-TTS-2, Catapres-TTS-3
Synonyms: Clonidine, CloNIDine
Generic Name: lidocaine
Brand name: UAD Caine, Xylocaine HCl, Xylocaine-MPF, Lidoject 1, Xylocaine Dental Cartridges, Lidoject 2, Xylocaine Duo-Trach Kit, Xylocaine HCl For Spinal, L-Caine, Dilocaine, Nervocaine, Truxacaine, Anestacaine
Synonyms: Lidocaine injection, Lidocaine (Systemic)
In the course of checking the drug compatibility and interactions, data from the following reference sources was used: Drugs.com, Rxlist.com, Webmd.com, Medscape.com.
- Clonidine Oral, Transdermal-Lidocaine Topical System
- Clonidine Oral, Transdermal-Lidocaine viscous
- Clonidine Oral, Transdermal-LidoCort
- Clonidine Oral, Transdermal-Lidoderm
- Clonidine Oral, Transdermal-Lidoderm Topical application
- Clonidine Oral, Transdermal-Lidodextrapine
- Lidocaine Topical Oral Solution 4%-Clonidine Patch
- Lidocaine Topical Oral Solution 4%-Clonidine Patches
- Lidocaine Topical Oral Solution 4%-Clonidine Tablets
- Lidocaine Topical Oral Solution 4%-Clonidine transdermal
- Lidocaine Topical Oral Solution 4%-Clopidogrel
- Lidocaine Topical Oral Solution 4%-Clopidogrel Bisulfate